NOL12_HUMAN
ID NOL12_HUMAN Reviewed; 213 AA.
AC Q9UGY1;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Nucleolar protein 12;
GN Name=NOL12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12529303; DOI=10.1101/gr.695703;
RA Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S.,
RA Bye J.M., Beare D.M., Dunham I.;
RT "Reevaluating human gene annotation: a second-generation analysis of
RT chromosome 22.";
RL Genome Res. 13:27-36(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH KIAA1191.
RX PubMed=21153684; DOI=10.1007/s11010-010-0690-4;
RA Mishra M., Inoue N., Heese K.;
RT "Characterizing the novel protein p33MONOX.";
RL Mol. Cell. Biochem. 350:127-134(2011).
CC -!- FUNCTION: May bind to 28S rRNA. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with KIAA1191. {ECO:0000269|PubMed:21153684}.
CC -!- INTERACTION:
CC Q9UGY1; Q8N7W2-2: BEND7; NbExp=3; IntAct=EBI-716098, EBI-10181188;
CC Q9UGY1; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-716098, EBI-5278764;
CC Q9UGY1; Q8NHQ1: CEP70; NbExp=4; IntAct=EBI-716098, EBI-739624;
CC Q9UGY1; Q92997: DVL3; NbExp=3; IntAct=EBI-716098, EBI-739789;
CC Q9UGY1; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-716098, EBI-12012928;
CC Q9UGY1; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-716098, EBI-10172290;
CC Q9UGY1; P23508: MCC; NbExp=3; IntAct=EBI-716098, EBI-307531;
CC Q9UGY1; Q9UGY1: NOL12; NbExp=3; IntAct=EBI-716098, EBI-716098;
CC Q9UGY1; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-716098, EBI-12023934;
CC Q9UGY1; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-716098, EBI-2212028;
CC Q9UGY1; P54274: TERF1; NbExp=2; IntAct=EBI-716098, EBI-710997;
CC Q9UGY1; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-716098, EBI-947459;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRP17 family. {ECO:0000305}.
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DR EMBL; AL160132; CAB77148.1; -; mRNA.
DR EMBL; CR456463; CAG30349.1; -; mRNA.
DR EMBL; Z83844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002808; AAH02808.1; -; mRNA.
DR CCDS; CCDS13955.1; -.
DR RefSeq; NP_077289.1; NM_024313.2.
DR AlphaFoldDB; Q9UGY1; -.
DR SMR; Q9UGY1; -.
DR BioGRID; 122577; 214.
DR IntAct; Q9UGY1; 67.
DR MINT; Q9UGY1; -.
DR STRING; 9606.ENSP00000352021; -.
DR iPTMnet; Q9UGY1; -.
DR PhosphoSitePlus; Q9UGY1; -.
DR BioMuta; NOL12; -.
DR DMDM; 74761951; -.
DR EPD; Q9UGY1; -.
DR jPOST; Q9UGY1; -.
DR MassIVE; Q9UGY1; -.
DR MaxQB; Q9UGY1; -.
DR PaxDb; Q9UGY1; -.
DR PeptideAtlas; Q9UGY1; -.
DR PRIDE; Q9UGY1; -.
DR ProteomicsDB; 84270; -.
DR Antibodypedia; 73215; 77 antibodies from 22 providers.
DR DNASU; 79159; -.
DR Ensembl; ENST00000359114.9; ENSP00000352021.4; ENSG00000273899.5.
DR Ensembl; ENST00000438329.5; ENSP00000403059.1; ENSG00000273899.5.
DR Ensembl; ENST00000611699.1; ENSP00000482349.1; ENSG00000273899.5.
DR GeneID; 79159; -.
DR KEGG; hsa:79159; -.
DR MANE-Select; ENST00000359114.9; ENSP00000352021.4; NM_024313.3; NP_077289.1.
DR UCSC; uc003ato.2; human.
DR CTD; 79159; -.
DR GeneCards; NOL12; -.
DR HGNC; HGNC:28585; NOL12.
DR HPA; ENSG00000273899; Low tissue specificity.
DR neXtProt; NX_Q9UGY1; -.
DR OpenTargets; ENSG00000273899; -.
DR PharmGKB; PA145148362; -.
DR VEuPathDB; HostDB:ENSG00000273899; -.
DR eggNOG; KOG4709; Eukaryota.
DR GeneTree; ENSGT00390000015973; -.
DR HOGENOM; CLU_111183_0_0_1; -.
DR InParanoid; Q9UGY1; -.
DR OMA; HKEYVKM; -.
DR OrthoDB; 1635966at2759; -.
DR PhylomeDB; Q9UGY1; -.
DR TreeFam; TF323855; -.
DR PathwayCommons; Q9UGY1; -.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR SignaLink; Q9UGY1; -.
DR BioGRID-ORCS; 79159; 650 hits in 1086 CRISPR screens.
DR ChiTaRS; NOL12; human.
DR GeneWiki; NOL12; -.
DR GenomeRNAi; 79159; -.
DR Pharos; Q9UGY1; Tbio.
DR PRO; PR:Q9UGY1; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9UGY1; protein.
DR Bgee; ENSG00000273899; Expressed in sural nerve and 117 other tissues.
DR ExpressionAtlas; Q9UGY1; baseline and differential.
DR Genevisible; Q9UGY1; HS.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR InterPro; IPR019186; Nucleolar_protein_12.
DR PANTHER; PTHR14577; PTHR14577; 1.
DR Pfam; PF09805; Nop25; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Reference proteome; RNA-binding; rRNA-binding.
FT CHAIN 1..213
FT /note="Nucleolar protein 12"
FT /id="PRO_0000271207"
FT REGION 118..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 33..96
FT /evidence="ECO:0000255"
FT COMPBIAS 130..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..186
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 213 AA; 24663 MW; 86A4DFBD363179CA CRC64;
MGRNKKKKRD GDDRRPRLVL SFDEEKRREY LTGFHKRKVE RKKAAIEEIK QRLKEEQRKL
REERHQEYLK MLAEREEALE EADELDRLVT AKTESVQYDH PNHTVTVTTI SDLDLSGARL
LGLTPPEGGA GDRSEEEASS TEKPTKALPR KSRDPLLSQR ISSLTASLHA HSRKKVKRKH
PRRAQDSKKP PRAPRTSKAQ RRRLTGKARH SGE
