NOL12_RAT
ID NOL12_RAT Reviewed; 216 AA.
AC Q5D1Z3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Nucleolar protein 12;
DE AltName: Full=25 kDa nucleolar protein;
GN Name=Nol12; Synonyms=Nop25;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RX PubMed=16430885; DOI=10.1016/j.yexcr.2005.12.017;
RA Suzuki S., Kanno M., Fujiwara T., Sugiyama H., Yokoyama A., Takahashi H.,
RA Tanaka J.;
RT "Molecular cloning and characterization of Nop25, a novel nucleolar RNA
RT binding protein, highly conserved in vertebrate species.";
RL Exp. Cell Res. 312:1031-1041(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May bind to 28S rRNA. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with KIAA1191. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRP17 family. {ECO:0000305}.
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DR EMBL; AY917132; AAX12419.1; -; mRNA.
DR EMBL; BC103643; AAI03644.1; -; mRNA.
DR RefSeq; NP_001012765.1; NM_001012747.2.
DR AlphaFoldDB; Q5D1Z3; -.
DR SMR; Q5D1Z3; -.
DR STRING; 10116.ENSRNOP00000013764; -.
DR PhosphoSitePlus; Q5D1Z3; -.
DR PaxDb; Q5D1Z3; -.
DR Ensembl; ENSRNOT00000013764; ENSRNOP00000013764; ENSRNOG00000010209.
DR GeneID; 362955; -.
DR KEGG; rno:362955; -.
DR CTD; 79159; -.
DR RGD; 1305327; Nol12.
DR eggNOG; KOG4709; Eukaryota.
DR GeneTree; ENSGT00390000015973; -.
DR HOGENOM; CLU_111183_0_0_1; -.
DR InParanoid; Q5D1Z3; -.
DR OMA; HKEYVKM; -.
DR OrthoDB; 1635966at2759; -.
DR PhylomeDB; Q5D1Z3; -.
DR TreeFam; TF323855; -.
DR PRO; PR:Q5D1Z3; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000010209; Expressed in skeletal muscle tissue and 19 other tissues.
DR Genevisible; Q5D1Z3; RN.
DR GO; GO:0005730; C:nucleolus; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0003723; F:RNA binding; IDA:RGD.
DR GO; GO:0019843; F:rRNA binding; IDA:MGI.
DR GO; GO:0003697; F:single-stranded DNA binding; IDA:RGD.
DR InterPro; IPR019186; Nucleolar_protein_12.
DR PANTHER; PTHR14577; PTHR14577; 1.
DR Pfam; PF09805; Nop25; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Reference proteome; RNA-binding; rRNA-binding.
FT CHAIN 1..216
FT /note="Nucleolar protein 12"
FT /id="PRO_0000271210"
FT REGION 120..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 33..97
FT /evidence="ECO:0000255"
FT COMPBIAS 137..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..186
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 216 AA; 25186 MW; AD106673D3753B0F CRC64;
MGRNKKKKRD GDDRRPRLIL NFDEEKRREY LTGFHKRKVE RKKAAIEEIK QRLKQEQKKL
REERHQEYLK MLAEREEALE EADELERLVT AKTESVQYDH PNHTVTVTTV SDLDLSGARL
LGLPLPEQGD QDGSQEEEVS SMEKPTKALP KKSKDPLLSQ RISSLTATLH AHSRKKVKRK
HPRRAQDSTK KPPSATRTSK TQRRRRMTGK ARHNGE