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NOL12_RAT
ID   NOL12_RAT               Reviewed;         216 AA.
AC   Q5D1Z3;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Nucleolar protein 12;
DE   AltName: Full=25 kDa nucleolar protein;
GN   Name=Nol12; Synonyms=Nop25;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RX   PubMed=16430885; DOI=10.1016/j.yexcr.2005.12.017;
RA   Suzuki S., Kanno M., Fujiwara T., Sugiyama H., Yokoyama A., Takahashi H.,
RA   Tanaka J.;
RT   "Molecular cloning and characterization of Nop25, a novel nucleolar RNA
RT   binding protein, highly conserved in vertebrate species.";
RL   Exp. Cell Res. 312:1031-1041(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May bind to 28S rRNA. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with KIAA1191. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRP17 family. {ECO:0000305}.
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DR   EMBL; AY917132; AAX12419.1; -; mRNA.
DR   EMBL; BC103643; AAI03644.1; -; mRNA.
DR   RefSeq; NP_001012765.1; NM_001012747.2.
DR   AlphaFoldDB; Q5D1Z3; -.
DR   SMR; Q5D1Z3; -.
DR   STRING; 10116.ENSRNOP00000013764; -.
DR   PhosphoSitePlus; Q5D1Z3; -.
DR   PaxDb; Q5D1Z3; -.
DR   Ensembl; ENSRNOT00000013764; ENSRNOP00000013764; ENSRNOG00000010209.
DR   GeneID; 362955; -.
DR   KEGG; rno:362955; -.
DR   CTD; 79159; -.
DR   RGD; 1305327; Nol12.
DR   eggNOG; KOG4709; Eukaryota.
DR   GeneTree; ENSGT00390000015973; -.
DR   HOGENOM; CLU_111183_0_0_1; -.
DR   InParanoid; Q5D1Z3; -.
DR   OMA; HKEYVKM; -.
DR   OrthoDB; 1635966at2759; -.
DR   PhylomeDB; Q5D1Z3; -.
DR   TreeFam; TF323855; -.
DR   PRO; PR:Q5D1Z3; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000010209; Expressed in skeletal muscle tissue and 19 other tissues.
DR   Genevisible; Q5D1Z3; RN.
DR   GO; GO:0005730; C:nucleolus; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0003723; F:RNA binding; IDA:RGD.
DR   GO; GO:0019843; F:rRNA binding; IDA:MGI.
DR   GO; GO:0003697; F:single-stranded DNA binding; IDA:RGD.
DR   InterPro; IPR019186; Nucleolar_protein_12.
DR   PANTHER; PTHR14577; PTHR14577; 1.
DR   Pfam; PF09805; Nop25; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Reference proteome; RNA-binding; rRNA-binding.
FT   CHAIN           1..216
FT                   /note="Nucleolar protein 12"
FT                   /id="PRO_0000271210"
FT   REGION          120..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          33..97
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        137..151
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..186
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   216 AA;  25186 MW;  AD106673D3753B0F CRC64;
     MGRNKKKKRD GDDRRPRLIL NFDEEKRREY LTGFHKRKVE RKKAAIEEIK QRLKQEQKKL
     REERHQEYLK MLAEREEALE EADELERLVT AKTESVQYDH PNHTVTVTTV SDLDLSGARL
     LGLPLPEQGD QDGSQEEEVS SMEKPTKALP KKSKDPLLSQ RISSLTATLH AHSRKKVKRK
     HPRRAQDSTK KPPSATRTSK TQRRRRMTGK ARHNGE
 
 
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