NOL4L_HUMAN
ID NOL4L_HUMAN Reviewed; 436 AA.
AC Q96MY1; Q5JYB7; Q6P0Y4; Q9BR34; Q9NQF6;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2003, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Nucleolar protein 4-like;
GN Name=NOL4L; Synonyms=C20orf112, C20orf113;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Neuron;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND SER-295, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q96MY1; Q13363-2: CTBP1; NbExp=3; IntAct=EBI-6660790, EBI-10171858;
CC Q96MY1; P56545: CTBP2; NbExp=3; IntAct=EBI-6660790, EBI-741533;
CC Q96MY1; P56545-3: CTBP2; NbExp=3; IntAct=EBI-6660790, EBI-10171902;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96MY1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96MY1-2; Sequence=VSP_014667, VSP_014668;
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DR EMBL; AK056286; BAB71138.1; -; mRNA.
DR EMBL; AL034550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC065370; AAH65370.1; -; mRNA.
DR CCDS; CCDS13202.1; -. [Q96MY1-1]
DR RefSeq; NP_001243727.1; NM_001256798.1.
DR RefSeq; NP_542183.2; NM_080616.4. [Q96MY1-1]
DR RefSeq; XP_005260345.1; XM_005260288.2. [Q96MY1-1]
DR RefSeq; XP_005260346.1; XM_005260289.4. [Q96MY1-1]
DR RefSeq; XP_016883158.1; XM_017027669.1. [Q96MY1-1]
DR AlphaFoldDB; Q96MY1; -.
DR BioGRID; 126651; 11.
DR IntAct; Q96MY1; 6.
DR STRING; 9606.ENSP00000483523; -.
DR GlyGen; Q96MY1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96MY1; -.
DR PhosphoSitePlus; Q96MY1; -.
DR BioMuta; NOL4L; -.
DR DMDM; 28212212; -.
DR EPD; Q96MY1; -.
DR jPOST; Q96MY1; -.
DR MassIVE; Q96MY1; -.
DR MaxQB; Q96MY1; -.
DR PaxDb; Q96MY1; -.
DR PeptideAtlas; Q96MY1; -.
DR PRIDE; Q96MY1; -.
DR ProteomicsDB; 77430; -. [Q96MY1-1]
DR ProteomicsDB; 77431; -. [Q96MY1-2]
DR Antibodypedia; 49998; 138 antibodies from 18 providers.
DR DNASU; 140688; -.
DR Ensembl; ENST00000359676.9; ENSP00000352704.5; ENSG00000197183.15. [Q96MY1-1]
DR GeneID; 140688; -.
DR KEGG; hsa:140688; -.
DR UCSC; uc002wxu.6; human. [Q96MY1-1]
DR CTD; 140688; -.
DR DisGeNET; 140688; -.
DR GeneCards; NOL4L; -.
DR HGNC; HGNC:16106; NOL4L.
DR HPA; ENSG00000197183; Tissue enhanced (retina, testis).
DR MIM; 618893; gene.
DR neXtProt; NX_Q96MY1; -.
DR OpenTargets; ENSG00000197183; -.
DR PharmGKB; PA25652; -.
DR VEuPathDB; HostDB:ENSG00000197183; -.
DR eggNOG; ENOG502QR3R; Eukaryota.
DR GeneTree; ENSGT00940000157729; -.
DR HOGENOM; CLU_020587_2_0_1; -.
DR InParanoid; Q96MY1; -.
DR OMA; QGDTSFP; -.
DR OrthoDB; 1009964at2759; -.
DR PhylomeDB; Q96MY1; -.
DR TreeFam; TF325594; -.
DR PathwayCommons; Q96MY1; -.
DR SignaLink; Q96MY1; -.
DR BioGRID-ORCS; 140688; 24 hits in 1072 CRISPR screens.
DR ChiTaRS; NOL4L; human.
DR GenomeRNAi; 140688; -.
DR Pharos; Q96MY1; Tbio.
DR PRO; PR:Q96MY1; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q96MY1; protein.
DR Bgee; ENSG00000197183; Expressed in ileal mucosa and 166 other tissues.
DR ExpressionAtlas; Q96MY1; baseline and differential.
DR Genevisible; Q96MY1; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR039788; NOL4/NOL4L.
DR InterPro; IPR026746; NOL4L.
DR PANTHER; PTHR12449; PTHR12449; 1.
DR PANTHER; PTHR12449:SF19; PTHR12449:SF19; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..436
FT /note="Nucleolar protein 4-like"
FT /id="PRO_0000079456"
FT REGION 1..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 130
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 295
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 382..398
FT /note="TPTPSSTSTSRPVPTAQ -> SALSGEPPTRRWGCSSV (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014667"
FT VAR_SEQ 399..436
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014668"
FT CONFLICT 215
FT /note="K -> E (in Ref. 1; BAB71138)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 436 AA; 47215 MW; 139A07537D875DF8 CRC64;
MSDSTWMSAD PHLASSLSPS QDERMRSPQN LHSQEDDDSS SESGSGNGSS TLNPSTSSST
QGDPAFPEMN GNGAVAPMDF TTAAEDQPIN LCDKLPPATA LGTASYPSDG CGADGLRSRV
KYGVKTTPES PPYSSGSYDS IKTEVSGCPE DLTVGRAPTA DDDDDDHDDH EDNDKMNDSE
GMDPERLKAF NMFVRLFVDE NLDRMVPISK QPKEKIQAII ESCSRQFPEF QERARKRIRT
YLKSCRRMKK NGMEMTRPTP PHLTSAMAEN ILAAACESET RKAAKRMRLE IYQSSQDEPI
ALDKQHSRDS AAITHSTYSL PASSYSQDPV YANGGLNYSY RGYGALSSNL QPPASLQTGN
HSNGPTDLSM KGGASTTSTT PTPTPSSTST SRPVPTAQLS PTEISAVRQL IAGYRESAAF
LLRSADELEN LILQQN
