NOL4_MOUSE
ID NOL4_MOUSE Reviewed; 483 AA.
AC P60954;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Nucleolar protein 4;
GN Name=Nol4; Synonyms=Gm1262;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P60954-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P60954-2; Sequence=VSP_040778, VSP_040779, VSP_040780;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH56377.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK031008; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC056377; AAH56377.1; ALT_INIT; mRNA.
DR CCDS; CCDS29093.2; -. [P60954-1]
DR CCDS; CCDS50235.1; -. [P60954-2]
DR RefSeq; NP_001154955.1; NM_001161483.1. [P60954-2]
DR RefSeq; NP_950189.2; NM_199024.2. [P60954-1]
DR RefSeq; XP_006526062.1; XM_006525999.2.
DR AlphaFoldDB; P60954; -.
DR SMR; P60954; -.
DR BioGRID; 235122; 1.
DR iPTMnet; P60954; -.
DR PhosphoSitePlus; P60954; -.
DR EPD; P60954; -.
DR jPOST; P60954; -.
DR MaxQB; P60954; -.
DR PaxDb; P60954; -.
DR PRIDE; P60954; -.
DR ProteomicsDB; 293674; -. [P60954-1]
DR ProteomicsDB; 293675; -. [P60954-2]
DR Antibodypedia; 8389; 123 antibodies from 25 providers.
DR DNASU; 319211; -.
DR Ensembl; ENSMUST00000081423; ENSMUSP00000080150; ENSMUSG00000041923. [P60954-2]
DR Ensembl; ENSMUST00000097651; ENSMUSP00000095256; ENSMUSG00000041923. [P60954-1]
DR GeneID; 319211; -.
DR KEGG; mmu:319211; -.
DR UCSC; uc008efq.2; mouse. [P60954-2]
DR UCSC; uc008efr.2; mouse. [P60954-1]
DR CTD; 8715; -.
DR MGI; MGI:2441684; Nol4.
DR VEuPathDB; HostDB:ENSMUSG00000041923; -.
DR eggNOG; ENOG502QR3R; Eukaryota.
DR GeneTree; ENSGT00940000159992; -.
DR InParanoid; P60954; -.
DR PhylomeDB; P60954; -.
DR TreeFam; TF325594; -.
DR BioGRID-ORCS; 319211; 1 hit in 25 CRISPR screens.
DR ChiTaRS; Nol4; mouse.
DR PRO; PR:P60954; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; P60954; protein.
DR Bgee; ENSMUSG00000041923; Expressed in rostral migratory stream and 115 other tissues.
DR ExpressionAtlas; P60954; baseline and differential.
DR Genevisible; P60954; MM.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR InterPro; IPR026747; NOL4.
DR InterPro; IPR039788; NOL4/NOL4L.
DR PANTHER; PTHR12449; PTHR12449; 2.
DR PANTHER; PTHR12449:SF17; PTHR12449:SF17; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..483
FT /note="Nucleolar protein 4"
FT /id="PRO_0000096936"
FT REGION 210..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..88
FT /note="MESERDMYRQFQDWCLRTYGDSGKTKTVTRKKYERIVQLLNGSESSSTDNAK
FT FKFWVKSKGFQLGQPDEVRGGGGGAKQVLFVRVKTT -> MHERLFQAPSGGLSQ (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040778"
FT VAR_SEQ 412
FT /note="N -> NMFVRLFVDENLDRMVPISKQPKEKIQAIIDSCRRQFPEYQERARKR
FT IRTYLKSCRRMKRSGFEM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040779"
FT VAR_SEQ 480..483
FT /note="DPQI -> VLYINGNGTYSYHSYRGLGGLLSLDDTSSSGPTDLSMKRQLATG
FT SGSSSSSTSRPQLSPTEINAVRQLVAGYRESAAFLLRSADELENLILQQN (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040780"
SQ SEQUENCE 483 AA; 53479 MW; D322BC97D1BEF741 CRC64;
MESERDMYRQ FQDWCLRTYG DSGKTKTVTR KKYERIVQLL NGSESSSTDN AKFKFWVKSK
GFQLGQPDEV RGGGGGAKQV LFVRVKTTDG VGVDEKLSLR RVAVVEDFFD IIYSMHVETG
PNGEQIRKHA GQKRTYKAIS ESYAFLPREA VTRFLMSCSE CQKRMHLNPD GTDHKDNGKP
PTLVTSMIDY NMPITMAYMK HMKLQLLNSQ QDEDESSIES DEFDMSDSTR MSAVNSDLSS
NLEERMQSPQ TVHGQQDDDS AAESSNGNET LGHSSAASGG AHGREPEDSS SDGKTGLEQE
EQPLNLSDSP SSAQLTSEFR IDDQGSDGKN KYKNLLISDL KMEREARENG SKSPAHSYSS
YDSGKNESVD RGAEDLSLNR GDEDEDEHDE HEDSEKVNET DGVEAERLKA FNSRPIPSHL
TSAVAESILA SACESESRNA AKRMRLDKAQ DEAAPADKQC KPEAAQATYS TATVPGSQED
PQI
