NOL6_HUMAN
ID NOL6_HUMAN Reviewed; 1146 AA.
AC Q9H6R4; Q5T5M3; Q5T5M4; Q7L4G6; Q8N6I0; Q8TEY9; Q8TEZ0; Q8TEZ1; Q9H675;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Nucleolar protein 6;
DE AltName: Full=Nucleolar RNA-associated protein {ECO:0000303|PubMed:11895476};
DE Short=Nrap {ECO:0000303|PubMed:11895476};
GN Name=NOL6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND FUNCTION.
RX PubMed=11895476; DOI=10.1046/j.1356-9597.2001.00507.x;
RA Utama B., Kennedy D., Ru K., Mattick J.S.;
RT "Isolation and characterization of a new nucleolar protein, Nrap, that is
RT conserved from yeast to humans.";
RL Genes Cells 7:115-132(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 644-1146 (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=12429849; DOI=10.1091/mbc.e02-05-0271;
RA Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C.,
RA Greco A., Hochstrasser D.F., Diaz J.-J.;
RT "Functional proteomic analysis of human nucleolus.";
RL Mol. Biol. Cell 13:4100-4109(2002).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56; SER-283; SER-289 AND
RP SER-811, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP INTERACTION WITH RRP7A.
RX PubMed=33199730; DOI=10.1038/s41467-020-19658-0;
RA Farooq M., Lindbaek L., Krogh N., Doganli C., Keller C., Moennich M.,
RA Goncalves A.B., Sakthivel S., Mang Y., Fatima A., Andersen V.S.,
RA Hussain M.S., Eiberg H., Hansen L., Kjaer K.W., Gopalakrishnan J.,
RA Pedersen L.B., Moellgaard K., Nielsen H., Baig S.M., Tommerup N.,
RA Christensen S.T., Larsen L.A.;
RT "RRP7A links primary microcephaly to dysfunction of ribosome biogenesis,
RT resorption of primary cilia, and neurogenesis.";
RL Nat. Commun. 11:5816-5816(2020).
CC -!- FUNCTION: Probably associated with rRNA. {ECO:0000305|PubMed:11895476}.
CC -!- SUBUNIT: Interacts with RRP7A; required for NOL6 localization to
CC nucleolus. {ECO:0000269|PubMed:33199730}.
CC -!- INTERACTION:
CC Q9H6R4; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-2514288, EBI-1055254;
CC Q9H6R4-4; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-10307896, EBI-747107;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
CC Chromosome {ECO:0000250}. Note=Localizes to condensed chromosomes in
CC mitosis. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=Alpha, Long;
CC IsoId=Q9H6R4-1; Sequence=Displayed;
CC Name=2; Synonyms=Beta, Mid;
CC IsoId=Q9H6R4-2; Sequence=VSP_013532;
CC Name=3; Synonyms=Gamma, Short;
CC IsoId=Q9H6R4-3; Sequence=VSP_013531;
CC Name=4;
CC IsoId=Q9H6R4-4; Sequence=VSP_013530;
CC -!- SIMILARITY: Belongs to the NRAP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH08298.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB15189.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB15389.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AF361079; AAL74403.1; -; mRNA.
DR EMBL; AF361080; AAL74404.1; -; mRNA.
DR EMBL; AF361081; AAL74405.1; -; mRNA.
DR EMBL; AL356218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC008298; AAH08298.1; ALT_INIT; mRNA.
DR EMBL; BC008852; AAH08852.2; -; mRNA.
DR EMBL; BC030139; AAH30139.1; -; mRNA.
DR EMBL; AK025612; BAB15189.1; ALT_INIT; mRNA.
DR EMBL; AK026193; BAB15389.1; ALT_SEQ; mRNA.
DR CCDS; CCDS6543.1; -. [Q9H6R4-1]
DR CCDS; CCDS6544.1; -. [Q9H6R4-3]
DR RefSeq; NP_075068.2; NM_022917.4. [Q9H6R4-1]
DR RefSeq; NP_631981.2; NM_139235.3. [Q9H6R4-3]
DR PDB; 7MQ8; EM; 3.60 A; NH=1-1146.
DR PDB; 7MQ9; EM; 3.87 A; NH=1-1146.
DR PDB; 7MQA; EM; 2.70 A; NH=1-1146.
DR PDBsum; 7MQ8; -.
DR PDBsum; 7MQ9; -.
DR PDBsum; 7MQA; -.
DR AlphaFoldDB; Q9H6R4; -.
DR SMR; Q9H6R4; -.
DR BioGRID; 122391; 201.
DR IntAct; Q9H6R4; 49.
DR MINT; Q9H6R4; -.
DR STRING; 9606.ENSP00000297990; -.
DR GlyGen; Q9H6R4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9H6R4; -.
DR MetOSite; Q9H6R4; -.
DR PhosphoSitePlus; Q9H6R4; -.
DR SwissPalm; Q9H6R4; -.
DR BioMuta; NOL6; -.
DR DMDM; 62900709; -.
DR SWISS-2DPAGE; Q9H6R4; -.
DR EPD; Q9H6R4; -.
DR jPOST; Q9H6R4; -.
DR MassIVE; Q9H6R4; -.
DR MaxQB; Q9H6R4; -.
DR PaxDb; Q9H6R4; -.
DR PeptideAtlas; Q9H6R4; -.
DR PRIDE; Q9H6R4; -.
DR ProteomicsDB; 81016; -. [Q9H6R4-1]
DR ProteomicsDB; 81017; -. [Q9H6R4-2]
DR ProteomicsDB; 81018; -. [Q9H6R4-3]
DR ProteomicsDB; 81019; -. [Q9H6R4-4]
DR Antibodypedia; 25265; 126 antibodies from 22 providers.
DR DNASU; 65083; -.
DR Ensembl; ENST00000297990.9; ENSP00000297990.4; ENSG00000165271.17. [Q9H6R4-1]
DR Ensembl; ENST00000353159.6; ENSP00000313978.4; ENSG00000165271.17. [Q9H6R4-3]
DR GeneID; 65083; -.
DR KEGG; hsa:65083; -.
DR MANE-Select; ENST00000297990.9; ENSP00000297990.4; NM_022917.5; NP_075068.2.
DR UCSC; uc003zsy.4; human. [Q9H6R4-1]
DR CTD; 65083; -.
DR DisGeNET; 65083; -.
DR GeneCards; NOL6; -.
DR HGNC; HGNC:19910; NOL6.
DR HPA; ENSG00000165271; Low tissue specificity.
DR MIM; 611532; gene.
DR neXtProt; NX_Q9H6R4; -.
DR OpenTargets; ENSG00000165271; -.
DR PharmGKB; PA134979388; -.
DR VEuPathDB; HostDB:ENSG00000165271; -.
DR eggNOG; KOG2054; Eukaryota.
DR GeneTree; ENSGT00390000018619; -.
DR HOGENOM; CLU_394292_0_0_1; -.
DR InParanoid; Q9H6R4; -.
DR OMA; NPHGGKE; -.
DR OrthoDB; 176625at2759; -.
DR PhylomeDB; Q9H6R4; -.
DR PathwayCommons; Q9H6R4; -.
DR Reactome; R-HSA-6790901; rRNA modification in the nucleus and cytosol.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR SignaLink; Q9H6R4; -.
DR BioGRID-ORCS; 65083; 758 hits in 1061 CRISPR screens.
DR ChiTaRS; NOL6; human.
DR GeneWiki; NOL6; -.
DR GenomeRNAi; 65083; -.
DR Pharos; Q9H6R4; Tbio.
DR PRO; PR:Q9H6R4; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9H6R4; protein.
DR Bgee; ENSG00000165271; Expressed in tongue squamous epithelium and 188 other tissues.
DR ExpressionAtlas; Q9H6R4; baseline and differential.
DR Genevisible; Q9H6R4; HS.
DR GO; GO:0000794; C:condensed nuclear chromosome; ISS:UniProtKB.
DR GO; GO:0032545; C:CURI complex; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0034456; C:UTP-C complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR GO; GO:0006409; P:tRNA export from nucleus; IBA:GO_Central.
DR InterPro; IPR005554; NOL6/Upt22.
DR InterPro; IPR035082; Nrap_D1.
DR InterPro; IPR035367; Nrap_D2.
DR InterPro; IPR035368; Nrap_D3.
DR InterPro; IPR035369; Nrap_D4.
DR InterPro; IPR035370; Nrap_D5.
DR InterPro; IPR035371; Nrap_D6.
DR PANTHER; PTHR17972; PTHR17972; 1.
DR Pfam; PF03813; Nrap; 1.
DR Pfam; PF17403; Nrap_D2; 1.
DR Pfam; PF17404; Nrap_D3; 1.
DR Pfam; PF17405; Nrap_D4; 1.
DR Pfam; PF17406; Nrap_D5; 1.
DR Pfam; PF17407; Nrap_D6; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Chromosome; Coiled coil; Nucleus;
KW Phosphoprotein; Reference proteome; RNA-binding.
FT CHAIN 1..1146
FT /note="Nucleolar protein 6"
FT /id="PRO_0000215647"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..114
FT /evidence="ECO:0000255"
FT COMPBIAS 23..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 289
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 811
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 383..385
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013530"
FT VAR_SEQ 651..1097
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11895476"
FT /id="VSP_013531"
FT VAR_SEQ 999..1146
FT /note="TVFRPPLDIYDVLIRLSPRHIPRHRQAVDSPAASFCRGLLSQPGPSSLMPVL
FT GYDPPQLYLTQLREAFGDLALFFYDQHGGEVIGVLWKPTSFQPQPFKASSTKGRMVMSR
FT GGELVMVPNVEAILEDFAVLGEGLVQTVEARSERWTV -> WDPAKMWPF (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:11895476"
FT /id="VSP_013532"
FT VARIANT 52
FT /note="P -> S (in dbSNP:rs10971523)"
FT /id="VAR_053541"
FT VARIANT 723
FT /note="R -> W (in dbSNP:rs35135082)"
FT /id="VAR_053542"
FT CONFLICT 1098
FT /note="A -> T (in Ref. 1; AAL74405)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1146 AA; 127593 MW; 2E73D31BC3D4AF6B CRC64;
MGPAPAGEQL RGATGEPEVM EPALEGTGKE GKKASSRKRT LAEPPAKGLL QPVKLSRAEL
YKEPTNEELN RLRETEILFH SSLLRLQVEE LLKEVRLSEK KKDRIDAFLR EVNQRVVRVP
SVPETELTDQ AWLPAGVRVP LHQVPYAVKG CFRFLPPAQV TVVGSYLLGT CIRPDINVDV
ALTMPREILQ DKDGLNQRYF RKRALYLAHL AHHLAQDPLF GSVCFSYTNG CHLKPSLLLR
PRGKDERLVT VRLHPCPPPD FFRPCRLLPT KNNVRSAWYR GQSPAGDGSP EPPTPRYNTW
VLQDTVLESH LQLLSTILSS AQGLKDGVAL LKVWLRQREL DKGQGGFTGF LVSMLVVFLV
STRKIHTTMS GYQVLRSVLQ FLATTDLTVN GISLCLSSDP SLPALADFHQ AFSVVFLDSS
GHLNLCADVT ASTYHQVQHE ARLSMMLLDS RADDGFHLLL MTPKPMIRAF DHVLHLRPLS
RLQAACHRLK LWPELQDNGG DYVSAALGPL TTLLEQGLGA RLNLLAHSRP PVPEWDISQD
PPKHKDSGTL TLGLLLRPEG LTSVLELGPE ADQPEAAKFR QFWGSRSELR RFQDGAIREA
VVWEAASMSQ KRLIPHQVVT HLLALHADIP ETCVHYVGGP LDALIQGLKE TSSTGEEALV
AAVRCYDDLS RLLWGLEGLP LTVSAVQGAH PVLRYTEVFP PTPVRPAFSF YETLRERSSL
LPRLDKPCPA YVEPMTVVCH LEGSGQWPQD AEAVQRVRAA FQLRLAELLT QQHGLQCRAT
ATHTDVLKDG FVFRIRVAYQ REPQILKEVQ SPEGMISLRD TAASLRLERD TRQLPLLTSA
LHGLQQQHPA FSGVARLAKR WVRAQLLGEG FADESLDLVA AALFLHPEPF TPPSSPQVGF
LRFLFLVSTF DWKNNPLFVN LNNELTVEEQ VEIRSGFLAA RAQLPVMVIV TPQDRKNSVW
TQDGPSAQIL QQLVVLAAEA LPMLEKQLMD PRGPGDIRTV FRPPLDIYDV LIRLSPRHIP
RHRQAVDSPA ASFCRGLLSQ PGPSSLMPVL GYDPPQLYLT QLREAFGDLA LFFYDQHGGE
VIGVLWKPTS FQPQPFKASS TKGRMVMSRG GELVMVPNVE AILEDFAVLG EGLVQTVEAR
SERWTV
