NOL7_MOUSE
ID NOL7_MOUSE Reviewed; 254 AA.
AC Q9D7Z3; Q9CY79; Q9JJE2;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Nucleolar protein 7;
GN Name=Nol7; ORFNames=MNCb-1192;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Stomach, and Wolffian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D7Z3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D7Z3-2; Sequence=VSP_014793;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA95050.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB041566; BAA95050.1; ALT_FRAME; mRNA.
DR EMBL; AK008670; BAB25823.1; -; mRNA.
DR EMBL; AK019972; BAB31943.1; -; mRNA.
DR EMBL; AK032963; BAC28101.1; -; mRNA.
DR CCDS; CCDS36644.1; -. [Q9D7Z3-1]
DR RefSeq; NP_076043.2; NM_023554.2. [Q9D7Z3-1]
DR AlphaFoldDB; Q9D7Z3; -.
DR SMR; Q9D7Z3; -.
DR BioGRID; 213851; 5.
DR STRING; 10090.ENSMUSP00000071818; -.
DR iPTMnet; Q9D7Z3; -.
DR PhosphoSitePlus; Q9D7Z3; -.
DR EPD; Q9D7Z3; -.
DR jPOST; Q9D7Z3; -.
DR MaxQB; Q9D7Z3; -.
DR PaxDb; Q9D7Z3; -.
DR PeptideAtlas; Q9D7Z3; -.
DR PRIDE; Q9D7Z3; -.
DR ProteomicsDB; 252984; -. [Q9D7Z3-1]
DR ProteomicsDB; 252985; -. [Q9D7Z3-2]
DR Antibodypedia; 24978; 32 antibodies from 16 providers.
DR DNASU; 70078; -.
DR Ensembl; ENSMUST00000071926; ENSMUSP00000071818; ENSMUSG00000063200. [Q9D7Z3-1]
DR Ensembl; ENSMUST00000222499; ENSMUSP00000152581; ENSMUSG00000063200. [Q9D7Z3-2]
DR GeneID; 70078; -.
DR KEGG; mmu:70078; -.
DR UCSC; uc007qgb.1; mouse. [Q9D7Z3-2]
DR UCSC; uc007qgc.1; mouse. [Q9D7Z3-1]
DR CTD; 51406; -.
DR MGI; MGI:1917328; Nol7.
DR VEuPathDB; HostDB:ENSMUSG00000063200; -.
DR eggNOG; ENOG502S14X; Eukaryota.
DR GeneTree; ENSGT00390000004118; -.
DR HOGENOM; CLU_095368_0_0_1; -.
DR InParanoid; Q9D7Z3; -.
DR OMA; WACKEKA; -.
DR PhylomeDB; Q9D7Z3; -.
DR TreeFam; TF336320; -.
DR BioGRID-ORCS; 70078; 21 hits in 71 CRISPR screens.
DR ChiTaRS; Nol7; mouse.
DR PRO; PR:Q9D7Z3; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9D7Z3; protein.
DR Bgee; ENSMUSG00000063200; Expressed in medial ganglionic eminence and 261 other tissues.
DR ExpressionAtlas; Q9D7Z3; baseline and differential.
DR Genevisible; Q9D7Z3; MM.
DR GO; GO:0005694; C:chromosome; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR InterPro; IPR039626; NOL7.
DR InterPro; IPR012579; NOL7_C.
DR PANTHER; PTHR32337; PTHR32337; 1.
DR Pfam; PF08157; NUC129; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Nucleus; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..254
FT /note="Nucleolar protein 7"
FT /id="PRO_0000096938"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..61
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079"
FT CROSSLNK 127
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UMY1"
FT CROSSLNK 157
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UMY1"
FT VAR_SEQ 230..254
FT /note="AQKQQNAKRFKKRWMAKKMKKKTYK -> KIARSSVGFSSFYK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014793"
SQ SEQUENCE 254 AA; 28970 MW; 36DA16A5E6B97B89 CRC64;
MVQLRPRLSR IPAPAEAMVD EDQAASEEEE AEHGLLLAQP SSGAAAEPLD EEEDADDEAP
EELTFASAQA EAREEELRVR ASARRDKTLL KEKRKRREEL FIEQKKRKLL PDAVLEQLTT
ASEADIKKSP ENVKVNLKKK SEQHAKGRNS KKVKVQKVQS VGQIESYMAV RLKDEDLRDS
RQEAAKHFIH SCLYGSDSKR TTVNKFLSLN NKRSPVKKAA AQFLTSTWGA QKQQNAKRFK
KRWMAKKMKK KTYK
