NOL9_CAEEL
ID NOL9_CAEEL Reviewed; 549 AA.
AC Q9U3B6; D3YT82;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Polynucleotide 5'-hydroxyl-kinase nol-9;
DE EC=2.7.1.-;
DE AltName: Full=Nucleolar protein 9 homolog;
GN Name=nol-9; ORFNames=K09B11.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING
RP (ISOFORMS A AND B).
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q9U3B6-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q9U3B6-2; Sequence=VSP_040447;
CC -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC {ECO:0000305}.
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DR EMBL; Z83114; CAB63234.1; -; Genomic_DNA.
DR EMBL; Z83114; CBK19460.1; -; Genomic_DNA.
DR RefSeq; NP_001255744.1; NM_001268815.1. [Q9U3B6-1]
DR RefSeq; NP_001255745.1; NM_001268816.1. [Q9U3B6-2]
DR AlphaFoldDB; Q9U3B6; -.
DR SMR; Q9U3B6; -.
DR STRING; 6239.K09B11.2a; -.
DR EPD; Q9U3B6; -.
DR PaxDb; Q9U3B6; -.
DR PeptideAtlas; Q9U3B6; -.
DR EnsemblMetazoa; K09B11.2a.1; K09B11.2a.1; WBGene00010709. [Q9U3B6-1]
DR EnsemblMetazoa; K09B11.2b.1; K09B11.2b.1; WBGene00010709. [Q9U3B6-2]
DR GeneID; 187190; -.
DR KEGG; cel:CELE_K09B11.2; -.
DR UCSC; K09B11.2; c. elegans. [Q9U3B6-1]
DR CTD; 187190; -.
DR WormBase; K09B11.2a; CE19989; WBGene00010709; nol-9. [Q9U3B6-1]
DR WormBase; K09B11.2b; CE44574; WBGene00010709; nol-9. [Q9U3B6-2]
DR eggNOG; KOG2750; Eukaryota.
DR GeneTree; ENSGT00940000153668; -.
DR HOGENOM; CLU_555791_0_0_1; -.
DR InParanoid; Q9U3B6; -.
DR OMA; WRLKELT; -.
DR OrthoDB; 1217334at2759; -.
DR PhylomeDB; Q9U3B6; -.
DR Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q9U3B6; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00010709; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF16575; CLP1_P; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ATP-binding; Kinase; Nucleotide-binding; Nucleus;
KW Reference proteome; rRNA processing; Transferase.
FT CHAIN 1..549
FT /note="Polynucleotide 5'-hydroxyl-kinase nol-9"
FT /id="PRO_0000403779"
FT BINDING 190..197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..424
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_040447"
SQ SEQUENCE 549 AA; 61990 MW; B0ED69020CD4DB48 CRC64;
MEEVVRFECR DSNLEIYVVQ PGERLSIFGS CSFLCLAGNA SINDYNLPAV SCESSNFMKI
SAPQRMDVPA ILQVFKSGPS YKHARLKFRL KEVAPKNYEK IMEMIGTTEP SVFIFSKILD
FAEETVSGVV SNFLIHSSIQ KQIILPPHFF ISRDDFIIYP QQQEAQLKSQ MNRLNKLRND
GQRTTILPIG HKGAGKSNLM RSLVNRCLSN GYEHVYVLDC DIGQSEFTPC GCLSLTKVTS
PILGKPHGHQ RASFENSFFY GDITVRDINL YMDIFERLFN KFKVISEPGS VCIINSMGWV
TDEGAEILDG ITRVTDPELF VEIFRDQTEA RYQFLNRAEH NIVEIFANNS IGVIGLPPQK
RLPAALIREL TIVGYFSSRL PRPSLASFPK VAPYKLRFEN VTICVPVDLL VEDSHVFSSI
NTQIMALCIN NTDLKPRKLY GKDDLPSICV IDGNSPALQC IGFGIIRGVS VEERIIFVVT
PVDLLKLEEP PVLVRGMRIQ TPTMFYTADP YNRCPYVLND LEQGNSDNTL DGLYQPSVNT
TQFKRSRRF