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NOL9_CAEEL
ID   NOL9_CAEEL              Reviewed;         549 AA.
AC   Q9U3B6; D3YT82;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase nol-9;
DE            EC=2.7.1.-;
DE   AltName: Full=Nucleolar protein 9 homolog;
GN   Name=nol-9; ORFNames=K09B11.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING
RP   (ISOFORMS A AND B).
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q9U3B6-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q9U3B6-2; Sequence=VSP_040447;
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Z83114; CAB63234.1; -; Genomic_DNA.
DR   EMBL; Z83114; CBK19460.1; -; Genomic_DNA.
DR   RefSeq; NP_001255744.1; NM_001268815.1. [Q9U3B6-1]
DR   RefSeq; NP_001255745.1; NM_001268816.1. [Q9U3B6-2]
DR   AlphaFoldDB; Q9U3B6; -.
DR   SMR; Q9U3B6; -.
DR   STRING; 6239.K09B11.2a; -.
DR   EPD; Q9U3B6; -.
DR   PaxDb; Q9U3B6; -.
DR   PeptideAtlas; Q9U3B6; -.
DR   EnsemblMetazoa; K09B11.2a.1; K09B11.2a.1; WBGene00010709. [Q9U3B6-1]
DR   EnsemblMetazoa; K09B11.2b.1; K09B11.2b.1; WBGene00010709. [Q9U3B6-2]
DR   GeneID; 187190; -.
DR   KEGG; cel:CELE_K09B11.2; -.
DR   UCSC; K09B11.2; c. elegans. [Q9U3B6-1]
DR   CTD; 187190; -.
DR   WormBase; K09B11.2a; CE19989; WBGene00010709; nol-9. [Q9U3B6-1]
DR   WormBase; K09B11.2b; CE44574; WBGene00010709; nol-9. [Q9U3B6-2]
DR   eggNOG; KOG2750; Eukaryota.
DR   GeneTree; ENSGT00940000153668; -.
DR   HOGENOM; CLU_555791_0_0_1; -.
DR   InParanoid; Q9U3B6; -.
DR   OMA; WRLKELT; -.
DR   OrthoDB; 1217334at2759; -.
DR   PhylomeDB; Q9U3B6; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q9U3B6; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00010709; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; ATP-binding; Kinase; Nucleotide-binding; Nucleus;
KW   Reference proteome; rRNA processing; Transferase.
FT   CHAIN           1..549
FT                   /note="Polynucleotide 5'-hydroxyl-kinase nol-9"
FT                   /id="PRO_0000403779"
FT   BINDING         190..197
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..424
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_040447"
SQ   SEQUENCE   549 AA;  61990 MW;  B0ED69020CD4DB48 CRC64;
     MEEVVRFECR DSNLEIYVVQ PGERLSIFGS CSFLCLAGNA SINDYNLPAV SCESSNFMKI
     SAPQRMDVPA ILQVFKSGPS YKHARLKFRL KEVAPKNYEK IMEMIGTTEP SVFIFSKILD
     FAEETVSGVV SNFLIHSSIQ KQIILPPHFF ISRDDFIIYP QQQEAQLKSQ MNRLNKLRND
     GQRTTILPIG HKGAGKSNLM RSLVNRCLSN GYEHVYVLDC DIGQSEFTPC GCLSLTKVTS
     PILGKPHGHQ RASFENSFFY GDITVRDINL YMDIFERLFN KFKVISEPGS VCIINSMGWV
     TDEGAEILDG ITRVTDPELF VEIFRDQTEA RYQFLNRAEH NIVEIFANNS IGVIGLPPQK
     RLPAALIREL TIVGYFSSRL PRPSLASFPK VAPYKLRFEN VTICVPVDLL VEDSHVFSSI
     NTQIMALCIN NTDLKPRKLY GKDDLPSICV IDGNSPALQC IGFGIIRGVS VEERIIFVVT
     PVDLLKLEEP PVLVRGMRIQ TPTMFYTADP YNRCPYVLND LEQGNSDNTL DGLYQPSVNT
     TQFKRSRRF
 
 
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