NOM1_DROME
ID NOM1_DROME Reviewed; 854 AA.
AC Q9W020;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Nucleolar MIF4G domain-containing protein 1 homolog;
GN ORFNames=CG9004;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF47640.1; -; Genomic_DNA.
DR EMBL; BT010298; AAQ23616.1; -; mRNA.
DR RefSeq; NP_647717.1; NM_139460.2.
DR AlphaFoldDB; Q9W020; -.
DR SMR; Q9W020; -.
DR BioGRID; 63818; 1.
DR IntAct; Q9W020; 1.
DR STRING; 7227.FBpp0072768; -.
DR PaxDb; Q9W020; -.
DR PRIDE; Q9W020; -.
DR DNASU; 38303; -.
DR EnsemblMetazoa; FBtr0072890; FBpp0072768; FBgn0035336.
DR GeneID; 38303; -.
DR KEGG; dme:Dmel_CG9004; -.
DR UCSC; CG9004-RA; d. melanogaster.
DR FlyBase; FBgn0035336; CG9004.
DR VEuPathDB; VectorBase:FBgn0035336; -.
DR eggNOG; KOG2141; Eukaryota.
DR GeneTree; ENSGT00940000153458; -.
DR HOGENOM; CLU_006786_0_0_1; -.
DR InParanoid; Q9W020; -.
DR OMA; QFKQSIR; -.
DR OrthoDB; 307186at2759; -.
DR PhylomeDB; Q9W020; -.
DR BioGRID-ORCS; 38303; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38303; -.
DR PRO; PR:Q9W020; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035336; Expressed in ovary and 23 other tissues.
DR Genevisible; Q9W020; DM.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51366; MI; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..854
FT /note="Nucleolar MIF4G domain-containing protein 1 homolog"
FT /id="PRO_0000286825"
FT DOMAIN 352..553
FT /note="MIF4G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT DOMAIN 650..764
FT /note="MI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..101
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..286
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 99116 MW; 41A648A2EE918E2A CRC64;
MAKIKKKEAK AKPLTRKEQR KQKSEFKKQN KRLYFAGKTN GTQRVAAAAE ALAAQSQLGK
NKKKKRSKKP KIINPDEIPK EQLLSGEIDS DDDESIDSDF SDAEVDALLP AREKMEVYEP
LGKKVKKTTG GAIQRQDEEA VRRKELRQQK ELESKSKKQR IKQLRIENEE DDREINKLEK
KLKLNKSKDK NRLVRKMFND GLDYLLDFVL DDEEEKRKWE EKQERKKKLK EQQEKEEAGM
WSDEEEDKED RDEPMDNFSE DDSGSEGEDD DEDLTGEEEQ SEEDSEQEEN APKIKEDIYG
RKRDAEGNIL PDPVELEASA AGQKYIPPHQ RALMAASAGS SEKQAEILAR LLKQCKGLLN
RLSEANLHKI AAGIEELYMK NSRYNMNETL TKLIQEALLG YTRTNERMVQ EHMVLLAYLH
AQVGSEIGAH FLQTFVELFD GYVKNIATLE VEDKQLNNLV LVLCYMYLFK IYELNLLMEL
IGKLSDQLCE KSVECLLLIF QSIGFRLRKD DPLAFKTMMQ KVQSQIASAP LELKENPRLR
FMVDILNAVK NNNMQKLPQY DPELAENLRK RLKAMLKNDR YVVTLNITLE DLLRADKVGK
WWIVGSAWTG NLDEMGSAKQ KQDKNSSKSA NGGFADQLLE LARKQQMNTA ERRNIFCIIM
SAADYVDAFE KILHLSLKDQ RAVAYVIIHC ALNEKRANPY YAHLALKFCQ FNRKYQLAFQ
FASWDRINDI EKLSKPQIRN LASFLQQVIL AAGLQLSVLK VVDFMQLDKL SFYFMKEVMV
RLLLANDERE IYQTFERVAK NTKLQQFKQS VRLFLQHFLL QEEQLDKLKL KDEDRQLLQQ
RVDHIDKLLA YVDL
