NOOT1_MEDTR
ID NOOT1_MEDTR Reviewed; 482 AA.
AC Q2HW56; G8GTN4;
DT 05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=BTB/POZ domain and ankyrin repeat-containing protein NOOT1 {ECO:0000305};
DE AltName: Full=Protein NODULE ROOT 1 {ECO:0000303|PubMed:30026291};
DE Short=MtNOOT1 {ECO:0000303|PubMed:30026291};
GN Name=NOOT1 {ECO:0000303|PubMed:30026291};
GN Synonyms=NOOT {ECO:0000303|PubMed:23136374};
GN OrderedLocusNames=MTR_7g090020 {ECO:0000312|EMBL:AES81230.1};
GN ORFNames=MtrDRAFT_AC147961g14v2 {ECO:0000312|EMBL:ABD28327.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY,
RP INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Jemalong A17, and cv. R108;
RX PubMed=23136374; DOI=10.1105/tpc.112.103747;
RA Couzigou J.M., Zhukov V., Mondy S., Abu El Heba G., Cosson V., Ellis T.H.,
RA Ambrose M., Wen J., Tadege M., Tikhonovich I., Mysore K.S., Putterill J.,
RA Hofer J., Borisov A.Y., Ratet P.;
RT "NODULE ROOT and COCHLEATA maintain nodule development and are legume
RT orthologs of Arabidopsis BLADE-ON-PETIOLE genes.";
RL Plant Cell 24:4498-4510(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17;
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E.D., Geurts R., Cannon S.B.,
RA Udvardi M.K., Benedito V.A., Mayer K.F.X., Gouzy J., Schoof H.,
RA Van de Peer Y., Proost S., Cook D.R., Meyers B.C., Spannagl M., Cheung F.,
RA De Mita S., Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K.,
RA Murray J.D., Naoumkina M.A., Rosen B., Silverstein K.A.T., Tang H.,
RA Rombauts S., Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M.,
RA Bellec A., Berger A., Berges H., Bidwell S., Bisseling T., Choisne N.,
RA Couloux A., Denny R., Deshpande S., Dai X., Doyle J.J., Dudez A.-M.,
RA Farmer A.D., Fouteau S., Franken C., Gibelin C., Gish J., Goldstein S.,
RA Gonzalez A.J., Green P.J., Hallab A., Hartog M., Hua A., Humphray S.J.,
RA Jeong D.-H., Jing Y., Jocker A., Kenton S.M., Kim D.-J., Klee K., Lai H.,
RA Lang C., Lin S., Macmil S.L., Magdelenat G., Matthews L., McCorrison J.,
RA Monaghan E.L., Mun J.-H., Najar F.Z., Nicholson C., Noirot C.,
RA O'Bleness M., Paule C.R., Poulain J., Prion F., Qin B., Qu C., Retzel E.F.,
RA Riddle C., Sallet E., Samain S., Samson N., Sanders I., Saurat O.,
RA Scarpelli C., Schiex T., Segurens B., Severin A.J., Sherrier D.J., Shi R.,
RA Sims S., Singer S.R., Sinharoy S., Sterck L., Viollet A., Wang B.-B.,
RA Wang K., Wang M., Wang X., Warfsmann J., Weissenbach J., White D.D.,
RA White J.D., Wiley G.B., Wincker P., Xing Y., Yang L., Yao Z., Ying F.,
RA Zhai J., Zhou L., Zuber A., Denarie J., Dixon R.A., May G.D.,
RA Schwartz D.C., Rogers J., Quetier F., Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17;
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17;
RX PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 4:1017-1025(2018).
RN [5]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=30026291; DOI=10.1104/pp.18.00610;
RA Magne K., Couzigou J.M., Schiessl K., Liu S., George J., Zhukov V.,
RA Sahl L., Boyer F., Iantcheva A., Mysore K.S., Wen J., Citerne S.,
RA Oldroyd G.E.D., Ratet P.;
RT "MtNODULE ROOT1 and MtNODULE ROOT2 are essential for indeterminate nodule
RT identity.";
RL Plant Physiol. 178:295-316(2018).
CC -!- FUNCTION: Involved in the promotion of leaf and floral meristem fate
CC and determinacy (PubMed:23136374). Promotes normal stipule growth and
CC development (PubMed:23136374). Involved in the coordination of the
CC symbiotic nodule developmental program (PubMed:23136374). Necessary for
CC the robust maintenance of nodule identity throughout the nodule
CC developmental program (PubMed:23136374). Involved in the regulation of
CC indeterminate nodule identity in association with NOOT2
CC (PubMed:30026291). {ECO:0000269|PubMed:23136374,
CC ECO:0000269|PubMed:30026291}.
CC -!- TISSUE SPECIFICITY: Expressed in the shoot apical meristem (SAM) at the
CC base of the developing leaf where stipules are formed.
CC {ECO:0000269|PubMed:23136374}.
CC -!- INDUCTION: Induced in roots during nodulation.
CC {ECO:0000269|PubMed:23136374, ECO:0000269|PubMed:30026291}.
CC -!- DISRUPTION PHENOTYPE: Altered morphology of stipules and flowers
CC (PubMed:23136374). Partial loss of nodule identity characterized by the
CC development of ectopic roots arising from nodule vascular meristems
CC (PubMed:23136374). The double mutants noot1 and noot2 exhibit complete
CC loss of nodule identity and develop only non-fixing root-like
CC structures that are no longer able to host symbiotic rhizobia
CC (PubMed:30026291). {ECO:0000269|PubMed:23136374,
CC ECO:0000269|PubMed:30026291}.
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DR EMBL; JN180856; AET34786.1; -; Genomic_DNA.
DR EMBL; JN180857; AET34787.1; -; Genomic_DNA.
DR EMBL; JN180858; AET34788.1; -; mRNA.
DR EMBL; JN180859; AET34789.1; -; mRNA.
DR EMBL; AC147961; ABD28327.1; -; Genomic_DNA.
DR EMBL; CM001223; AES81230.1; -; Genomic_DNA.
DR EMBL; PSQE01000007; RHN47744.1; -; Genomic_DNA.
DR RefSeq; XP_003625012.1; XM_003624964.2.
DR AlphaFoldDB; Q2HW56; -.
DR SMR; Q2HW56; -.
DR STRING; 3880.AES81230; -.
DR EnsemblPlants; AES81230; AES81230; MTR_7g090020.
DR GeneID; 11417633; -.
DR Gramene; AES81230; AES81230; MTR_7g090020.
DR KEGG; mtr:MTR_7g090020; -.
DR eggNOG; KOG0504; Eukaryota.
DR HOGENOM; CLU_028148_0_0_1; -.
DR OMA; EPRPSCG; -.
DR OrthoDB; 651575at2759; -.
DR Proteomes; UP000002051; Chromosome 7.
DR Proteomes; UP000265566; Chromosome 7.
DR ExpressionAtlas; Q2HW56; differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0009864; P:induced systemic resistance, jasmonic acid mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0009877; P:nodulation; IMP:UniProtKB.
DR GO; GO:0010865; P:stipule development; IMP:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR044284; NPR5/6.
DR InterPro; IPR024228; NPR_central_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR46668; PTHR46668; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF11900; DUF3420; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Nodulation; Reference proteome; Repeat.
FT CHAIN 1..482
FT /note="BTB/POZ domain and ankyrin repeat-containing protein
FT NOOT1"
FT /id="PRO_0000445727"
FT DOMAIN 25..107
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 249..278
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 279..308
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 313..342
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REGION 395..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 402
FT /note="S -> SN (in Ref. 1; AET34786/AET34788)"
FT /evidence="ECO:0000305"
FT CONFLICT 427
FT /note="H -> R (in Ref. 1; AET34786/AET34788)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 482 AA; 53316 MW; 2865EB0C97BADCED CRC64;
MSLEDSLRSL SLDYLNLLIN GQAFSDVVFS VEGRLVHAHR CILAARSLFF RKFFCGPDPP
SGLDPSGNRV NPSGSARSGV IPVNSVGYEV FLLMLQFLYS GQVSIVPQKH EPRPNCGDRG
CWHTHCTSAV DLALDTLAAA RYFGVEQLAL LTQKQLASMV EKASIEDVMK VLLASRKQDM
HQLWTTCSHL VAKSGLPPEV LAKHLPIDII AKIEELRIKT SLSRRSLMPH HHHPHHHDHL
TAAADLEDQK IRRMRRALDS SDVELVKLMV MGEGLNLDEA LALPYAVENC SREVVKALLE
LGAADVNFPA GPTGKTPLHI AAEMVSPDMV AVLLDHHADP NVRTVDGVTP LDILRTLTSD
FLFKGAVPGL THIEPNKLRL CLELVQSAAL VMSREEGNNN NSNNNNNATA SSATNMYPHH
NMNEDHHHSH NNNNMDSRLV YLNLGANTQM STSRMDSGDD DNTHREAINN SMYHHHSHGH
DY
