ID   NOP10_ASHGO             Reviewed;          57 AA.
AC   Q74Z52;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit NOP10;
DE   AltName: Full=Nucleolar protein 10;
DE   AltName: Full=Nucleolar protein family A member 3;
DE   AltName: Full=snoRNP protein NOP10;
GN   Name=NOP10; OrderedLocusNames=AGR354W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Non-catalytic component of the H/ACA small nucleolar
CC       ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of
CC       rRNA and is required for ribosome biogenesis. This involves the
CC       isomerization of uridine such that the ribose is subsequently attached
CC       to C5, instead of the normal N1. Pseudouridine ('psi') residues may
CC       serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex
CC       also mediates pseudouridylation of other types of RNAs. The H/ACA
CC       snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
CC       {ECO:0000250|UniProtKB:Q6Q547}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC       {ECO:0000250|UniProtKB:Q6Q547}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q6Q547}.
CC   -!- SIMILARITY: Belongs to the NOP10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS54844.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016820; AAS54844.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_987020.1; NM_212082.1.
DR   AlphaFoldDB; Q74Z52; -.
DR   SMR; Q74Z52; -.
DR   STRING; 33169.AAS54844; -.
DR   PRIDE; Q74Z52; -.
DR   GeneID; 4623323; -.
DR   KEGG; ago:AGOS_AGR354W; -.
DR   eggNOG; KOG3503; Eukaryota.
DR   InParanoid; Q74Z52; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR   GO; GO:0090661; C:box H/ACA telomerase RNP complex; IBA:GO_Central.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR   GO; GO:0070034; F:telomerase RNA binding; IBA:GO_Central.
DR   GO; GO:0031118; P:rRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0031120; P:snRNA pseudouridine synthesis; IBA:GO_Central.
DR   InterPro; IPR007264; H/ACA_rnp_Nop10.
DR   InterPro; IPR036756; H/ACA_rnp_Nop10_sf.
DR   PANTHER; PTHR13305; PTHR13305; 1.
DR   Pfam; PF04135; Nop10p; 1.
DR   SUPFAM; SSF144210; SSF144210; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..57
FT                   /note="H/ACA ribonucleoprotein complex subunit NOP10"
FT                   /id="PRO_0000149008"
SQ   SEQUENCE   57 AA;  6680 MW;  04159912BDB6593A CRC64;
     MHLMYTLGPD GKRVYTLEKV TPSGEITKSA HPARFSPDDK YSRQRVTLKR RFDMLPR