NOP10_CANGA
ID NOP10_CANGA Reviewed; 57 AA.
AC Q6FNL3;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=H/ACA ribonucleoprotein complex subunit NOP10;
DE AltName: Full=Nucleolar protein 10;
DE AltName: Full=Nucleolar protein family A member 3;
DE AltName: Full=snoRNP protein NOP10;
GN Name=NOP10; OrderedLocusNames=CAGL0J10802g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Non-catalytic component of the H/ACA small nucleolar
CC ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of
CC rRNA and is required for ribosome biogenesis. This involves the
CC isomerization of uridine such that the ribose is subsequently attached
CC to C5, instead of the normal N1. Pseudouridine ('psi') residues may
CC serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex
CC also mediates pseudouridylation of other types of RNAs. The H/ACA
CC snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
CC {ECO:0000250|UniProtKB:Q6Q547}.
CC -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC {ECO:0000250|UniProtKB:Q6Q547}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q6Q547}.
CC -!- SIMILARITY: Belongs to the NOP10 family. {ECO:0000305}.
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DR EMBL; CR380956; CAG61132.1; -; Genomic_DNA.
DR RefSeq; XP_448181.1; XM_448181.1.
DR AlphaFoldDB; Q6FNL3; -.
DR SMR; Q6FNL3; -.
DR STRING; 5478.XP_448181.1; -.
DR EnsemblFungi; CAG61132; CAG61132; CAGL0J10802g.
DR GeneID; 2889619; -.
DR KEGG; cgr:CAGL0J10802g; -.
DR CGD; CAL0132862; CAGL0J10802g.
DR VEuPathDB; FungiDB:CAGL0J10802g; -.
DR eggNOG; KOG3503; Eukaryota.
DR HOGENOM; CLU_184680_1_0_1; -.
DR InParanoid; Q6FNL3; -.
DR OMA; MYTLGPD; -.
DR Proteomes; UP000002428; Chromosome J.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR007264; H/ACA_rnp_Nop10.
DR InterPro; IPR036756; H/ACA_rnp_Nop10_sf.
DR PANTHER; PTHR13305; PTHR13305; 1.
DR Pfam; PF04135; Nop10p; 1.
DR SUPFAM; SSF144210; SSF144210; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..57
FT /note="H/ACA ribonucleoprotein complex subunit NOP10"
FT /id="PRO_0000149009"
FT REGION 22..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 57 AA; 6815 MW; D167C19555BAAD75 CRC64;
MHLMYTLDNE GKRVYTLKKM TEEGEITKSA HPARFSPDDK YSRQRVTLKK RYNLLPQ