ID   NOP10_DANRE             Reviewed;          64 AA.
AC   Q6DRH5; Q504C4;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit 3;
DE   AltName: Full=Nucleolar protein 10;
DE   AltName: Full=Nucleolar protein family A member 3;
DE   AltName: Full=snoRNP protein NOP10;
GN   Name=nop10; Synonyms=nola3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA   Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA   Hopkins N.;
RT   "Identification of 315 genes essential for early zebrafish development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC       catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC       uridine such that the ribose is subsequently attached to C5, instead of
CC       the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC       the conformation of rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the
CC       telomerase holoenzyme complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q9NPE3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP10 family. {ECO:0000305}.
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DR   EMBL; AY648784; AAT68102.1; -; mRNA.
DR   EMBL; BC095081; AAH95081.1; -; mRNA.
DR   RefSeq; NP_001003868.1; NM_001003868.2.
DR   AlphaFoldDB; Q6DRH5; -.
DR   SMR; Q6DRH5; -.
DR   STRING; 7955.ENSDARP00000107682; -.
DR   PaxDb; Q6DRH5; -.
DR   Ensembl; ENSDART00000161015; ENSDARP00000132783; ENSDARG00000104227.
DR   GeneID; 445391; -.
DR   KEGG; dre:445391; -.
DR   CTD; 55505; -.
DR   ZFIN; ZDB-GENE-041007-4; nop10.
DR   eggNOG; KOG3503; Eukaryota.
DR   GeneTree; ENSGT00390000012563; -.
DR   HOGENOM; CLU_184680_1_0_1; -.
DR   InParanoid; Q6DRH5; -.
DR   OMA; MYTLGPD; -.
DR   OrthoDB; 1628018at2759; -.
DR   PhylomeDB; Q6DRH5; -.
DR   TreeFam; TF300211; -.
DR   Reactome; R-DRE-171319; Telomere Extension By Telomerase.
DR   PRO; PR:Q6DRH5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000104227; Expressed in gastrula and 23 other tissues.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR   GO; GO:0090661; C:box H/ACA telomerase RNP complex; IBA:GO_Central.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR   GO; GO:0070034; F:telomerase RNA binding; IBA:GO_Central.
DR   GO; GO:0060215; P:primitive hemopoiesis; IMP:ZFIN.
DR   GO; GO:0006364; P:rRNA processing; IMP:ZFIN.
DR   GO; GO:0031118; P:rRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0031120; P:snRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; ISS:UniProtKB.
DR   InterPro; IPR007264; H/ACA_rnp_Nop10.
DR   InterPro; IPR036756; H/ACA_rnp_Nop10_sf.
DR   PANTHER; PTHR13305; PTHR13305; 1.
DR   Pfam; PF04135; Nop10p; 1.
DR   SUPFAM; SSF144210; SSF144210; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..64
FT                   /note="H/ACA ribonucleoprotein complex subunit 3"
FT                   /id="PRO_0000149003"
FT   REGION          19..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   64 AA;  7446 MW;  3651D096C9131E6F CRC64;
     MFLQFYLNEN GERVYTLKKV DPSGQPTSSA HPARFSPDDK FSRHRVTIKK RFGLLLTQQP
     RPVL