NOP10_DROME
ID NOP10_DROME Reviewed; 64 AA.
AC Q9V5P6; Q4QPR2;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=H/ACA ribonucleoprotein complex subunit 3;
DE AltName: Full=Nucleolar protein 10;
DE AltName: Full=Nucleolar protein family A member 3;
DE AltName: Full=snoRNP protein dNop10;
GN ORFNames=CG7637;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INDUCTION.
RX PubMed=12426388; DOI=10.1093/emboj/cdf600;
RA Zinke I., Schuetz C.S., Katzenberger J.D., Bauer M., Pankratz M.J.;
RT "Nutrient control of gene expression in Drosophila: microarray analysis of
RT starvation and sugar-dependent response.";
RL EMBO J. 21:6162-6173(2002).
CC -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC uridine such that the ribose is subsequently attached to C5, instead of
CC the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC the conformation of rRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC containing H/ACA-type snoRNAs (H/ACA snoRNPs). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- INDUCTION: Repressed during starvation. {ECO:0000269|PubMed:12426388}.
CC -!- SIMILARITY: Belongs to the NOP10 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF58753.1; -; Genomic_DNA.
DR EMBL; BT023704; AAY85104.1; -; mRNA.
DR RefSeq; NP_610610.1; NM_136766.2.
DR AlphaFoldDB; Q9V5P6; -.
DR SMR; Q9V5P6; -.
DR BioGRID; 61943; 3.
DR IntAct; Q9V5P6; 2.
DR STRING; 7227.FBpp0087347; -.
DR PaxDb; Q9V5P6; -.
DR PRIDE; Q9V5P6; -.
DR DNASU; 36135; -.
DR EnsemblMetazoa; FBtr0088252; FBpp0087347; FBgn0033548.
DR GeneID; 36135; -.
DR KEGG; dme:Dmel_CG7637; -.
DR UCSC; CG7637-RA; d. melanogaster.
DR FlyBase; FBgn0033548; CG7637.
DR VEuPathDB; VectorBase:FBgn0033548; -.
DR eggNOG; KOG3503; Eukaryota.
DR GeneTree; ENSGT00390000012563; -.
DR HOGENOM; CLU_184680_1_0_1; -.
DR InParanoid; Q9V5P6; -.
DR OMA; MYTLGPD; -.
DR OrthoDB; 1628018at2759; -.
DR PhylomeDB; Q9V5P6; -.
DR BioGRID-ORCS; 36135; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 36135; -.
DR PRO; PR:Q9V5P6; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033548; Expressed in imaginal disc and 38 other tissues.
DR Genevisible; Q9V5P6; DM.
DR GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR GO; GO:0090661; C:box H/ACA telomerase RNP complex; IBA:GO_Central.
DR GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR GO; GO:0070034; F:telomerase RNA binding; IBA:GO_Central.
DR GO; GO:0031118; P:rRNA pseudouridine synthesis; IBA:GO_Central.
DR GO; GO:0031120; P:snRNA pseudouridine synthesis; IBA:GO_Central.
DR InterPro; IPR007264; H/ACA_rnp_Nop10.
DR InterPro; IPR036756; H/ACA_rnp_Nop10_sf.
DR PANTHER; PTHR13305; PTHR13305; 1.
DR Pfam; PF04135; Nop10p; 1.
DR SUPFAM; SSF144210; SSF144210; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..64
FT /note="H/ACA ribonucleoprotein complex subunit 3"
FT /id="PRO_0000149005"
SQ SEQUENCE 64 AA; 7634 MW; B957575E84DEA7CF CRC64;
MYLMYTINEN GDRVYTLKKR TEDGRPTLSA HPARFSPEDK YSRQRLTIKK RFGLLLTQKP
EPIY
