ID   NOP10_TRYCR             Reviewed;          63 AA.
AC   Q6JZK2;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit 3-like protein;
DE   AltName: Full=Nucleolar protein 10;
DE   AltName: Full=Ribosome biogenesis protein Nop10;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Vancini T.R.G., Picchi G.F.A., Krieger M.A., Goldenberg S., Fragoso S.P.;
RT   "Cloning and characterization of the gene encoding the putative Nop10
RT   protein in Trypanosoma cruzi.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC       catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC       uridine such that the ribose is subsequently attached to C5, instead of
CC       the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC       the conformation of rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP10 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY243571; AAP22988.1; -; mRNA.
DR   AlphaFoldDB; Q6JZK2; -.
DR   SMR; Q6JZK2; -.
DR   VEuPathDB; TriTrypDB:BCY84_16129; -.
DR   VEuPathDB; TriTrypDB:C3747_7g1097c; -.
DR   VEuPathDB; TriTrypDB:C4B63_13g978c; -.
DR   VEuPathDB; TriTrypDB:TcBrA4_0003040; -.
DR   VEuPathDB; TriTrypDB:TcCLB.503891.54; -.
DR   VEuPathDB; TriTrypDB:TcCLB.510289.6; -.
DR   VEuPathDB; TriTrypDB:TCDM_13837; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0080420; -.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR007264; H/ACA_rnp_Nop10.
DR   InterPro; IPR036756; H/ACA_rnp_Nop10_sf.
DR   PANTHER; PTHR13305; PTHR13305; 1.
DR   Pfam; PF04135; Nop10p; 1.
DR   SUPFAM; SSF144210; SSF144210; 1.
PE   3: Inferred from homology;
KW   Nucleus; Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..63
FT                   /note="H/ACA ribonucleoprotein complex subunit 3-like
FT                   protein"
FT                   /id="PRO_0000149006"
FT   REGION          18..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   63 AA;  7490 MW;  2D5AA88A8515369B CRC64;
     MHLQVYIVNG KRQYTLKKMD PEGKPTLSAH PARFSPDDKY SRHRITIKRR FKALKSEKRP
     KPL