ID   NOP12_ASHGO             Reviewed;         426 AA.
AC   Q75BJ7;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Nucleolar protein 12;
GN   Name=NOP12; OrderedLocusNames=ACR274W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
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DR   EMBL; AE016816; AAS51500.1; -; Genomic_DNA.
DR   RefSeq; NP_983676.1; NM_209029.1.
DR   AlphaFoldDB; Q75BJ7; -.
DR   SMR; Q75BJ7; -.
DR   STRING; 33169.AAS51500; -.
DR   EnsemblFungi; AAS51500; AAS51500; AGOS_ACR274W.
DR   GeneID; 4619811; -.
DR   KEGG; ago:AGOS_ACR274W; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   HOGENOM; CLU_006468_0_0_1; -.
DR   InParanoid; Q75BJ7; -.
DR   OMA; NAYAVYT; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030684; C:preribosome; IEA:EnsemblFungi.
DR   GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   CDD; cd12669; RRM1_Nop12p_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034777; Nop12_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..426
FT                   /note="Nucleolar protein 12"
FT                   /id="PRO_0000081664"
FT   DOMAIN          137..251
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          259..339
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          26..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   426 AA;  48253 MW;  382B0C5A8D0766EE CRC64;
     MSALNKLFGD ERKRDLESNV AALFSQSSGP VDTLEVKSKP RTLLPVVSKR QETETAKPAE
     PTEIVEADLP RKRAKKAKKT NEDDDHLEEK YMQQVLKEDS DHESEAEAPT EPVVELKPSK
     RASRPDMKEE ELAKAERTVF VGNVPHEAIT DKKVYKEFKQ LVAQRKLSKE DEDDEEQKAE
     KYAVESIRFR SIAFEEALPR KVAFVQQKLH HTRDSVNAYV VYAEKEAVTA ACKLNGSVFH
     DHHLRFDSVA HPAPHDRKRS VFVGNLDFEE SEESLWKHFM SCGPIEYVRI VRDPKTNVGK
     GFAYVQFADL VSVNKALLLN DKKMAVGKGR KLRVTRCRNM QKVQRQSNTA ALPKLTDQQK
     TKLGRARKVL GKADRATLGK LTIEGTRATK GANTPNLRVK KARSKTGRVT KRSQAFKKAE
     ANKKQK