NOP12_ASPFU
ID NOP12_ASPFU Reviewed; 538 AA.
AC Q4WCH5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Nucleolar protein 12;
GN Name=nop12; ORFNames=AFUA_8G04400;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
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DR EMBL; AAHF01000013; EAL85209.1; -; Genomic_DNA.
DR RefSeq; XP_747247.1; XM_742154.1.
DR AlphaFoldDB; Q4WCH5; -.
DR SMR; Q4WCH5; -.
DR STRING; 746128.CADAFUBP00008092; -.
DR EnsemblFungi; EAL85209; EAL85209; AFUA_8G04400.
DR GeneID; 3504782; -.
DR KEGG; afm:AFUA_8G04400; -.
DR VEuPathDB; FungiDB:Afu8g04400; -.
DR eggNOG; KOG0118; Eukaryota.
DR HOGENOM; CLU_006468_2_0_1; -.
DR InParanoid; Q4WCH5; -.
DR OMA; NAYAVYT; -.
DR OrthoDB; 1176212at2759; -.
DR Proteomes; UP000002530; Chromosome 8.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd12669; RRM1_Nop12p_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR034777; Nop12_RRM1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Repeat; Ribosome biogenesis;
KW RNA-binding; rRNA processing.
FT CHAIN 1..538
FT /note="Nucleolar protein 12"
FT /id="PRO_0000081665"
FT DOMAIN 203..315
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 323..435
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..156
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..94
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..519
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 538 AA; 58986 MW; AB7BA2EA06A87969 CRC64;
MGKKSKAQSD NVSQPGKTDV TLPFLGGKAA IDPTVASLFE KSAGPVKAPS VQPIITQRKE
NGPEDDVEKE EDDEEISELE EDLQSEDEDM QDVSEVAGDA ERTLAVDTQA PSSKKRKRAP
AEDLEETYMR RIAKEEQKEQ EKRRAEKAKR QKVEEGGKDS DPVSDKSKDG RDESSEEEDE
ITVPRHETQS GDPESKELEK SNRTVFLGNV SSQAIKSKSA KKTLLKHLAS FLSTLPESTG
PHKVESIRFR SVAFASGGKV PKRAAFARRE ILDDTTPSTN AYVVYSTVQA ARKAPAALNG
TVVLDRHLRV DSVAHPSQID HKRCVFVGNL DFVDNETDPE EDDKKKKKKK SGPADVEEGL
WRTFNAHTKG SKERASTRGN VESVRVVRDR TTRVGKGFAY VQFYDQVCVE EALLLDGKKF
PPMLPRKLRV TRAKKLPKKR DGPETGSHGK ALGEGFSTLQ GRAGKLFGRA GAAKMKAEGR
KSISGNSVVF EGNRASEGSS RIKIKTKSRG SKGKPKNRSA KRAAAYQAAG GRKGKMAK
