NOP12_CANAL
ID NOP12_CANAL Reviewed; 455 AA.
AC Q5AHI7; A0A1D8PH24;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Nucleolar protein 12;
GN Name=NOP12; OrderedLocusNames=CAALFM_C204120CA;
GN ORFNames=CaO19.809, CaO19.8429;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27438.1; -; Genomic_DNA.
DR RefSeq; XP_720933.2; XM_715840.2.
DR AlphaFoldDB; Q5AHI7; -.
DR SMR; Q5AHI7; -.
DR STRING; 237561.Q5AHI7; -.
DR PRIDE; Q5AHI7; -.
DR GeneID; 3637377; -.
DR KEGG; cal:CAALFM_C204120CA; -.
DR CGD; CAL0000199505; orf19.8429.
DR VEuPathDB; FungiDB:C2_04120C_A; -.
DR eggNOG; KOG0118; Eukaryota.
DR HOGENOM; CLU_006468_0_0_1; -.
DR InParanoid; Q5AHI7; -.
DR OrthoDB; 1176212at2759; -.
DR PRO; PR:Q5AHI7; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0030684; C:preribosome; IEA:EnsemblFungi.
DR GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR CDD; cd12669; RRM1_Nop12p_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR034777; Nop12_RRM1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; RNA-binding;
KW rRNA processing.
FT CHAIN 1..455
FT /note="Nucleolar protein 12"
FT /id="PRO_0000081666"
FT DOMAIN 160..258
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 266..351
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..89
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 51651 MW; FE585BBD93DC77C8 CRC64;
MSSFANLFGK STKVDENIEQ LFKNTRDGPV SKDELVKKQR TVIKIPKVTA PKQQTNENES
TLNQSANESD EEEEEYNDES NEGDDSDDAE QTEPTSKNDD ENENLEAQYF DKLLSEQNEE
QDESKESSEA KSSKVAEERT KAKVATTVDL KEKELEKADR TVFVGNVPAD VITSKIIAKN
FKNLFKHYGK IDSIRYRSIS FDEHLPRKVA FAKKNLHKSR DSVNAYIVYK EKPASIAAKE
LNATVFEDHH LRVDHVSHPA PKDNKRTIFV GNLDFEEKEE TLWKYFNSKL DQDVESVRII
RDSKTNLGKG FALVQFKDTL SVNKALLLND KPLETGTQKK GRKLRISRAK SNAKPSLMSP
NHFDNQKKKF AAGKSQQKLN DNQKTKIGRA QSTLGKADRS TVGKAKRIIL EGQRATKGEA
IKGIKGSKKG KKVKKPRIRE RSTKFKEERK TMNKV
