ID   NOP12_CANGA             Reviewed;         396 AA.
AC   Q6FUS6;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Nucleolar protein 12;
GN   Name=NOP12; OrderedLocusNames=CAGL0F01023g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
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DR   EMBL; CR380952; CAG58942.1; -; Genomic_DNA.
DR   RefSeq; XP_446018.1; XM_446018.1.
DR   AlphaFoldDB; Q6FUS6; -.
DR   SMR; Q6FUS6; -.
DR   STRING; 5478.XP_446018.1; -.
DR   EnsemblFungi; CAG58942; CAG58942; CAGL0F01023g.
DR   GeneID; 2887717; -.
DR   KEGG; cgr:CAGL0F01023g; -.
DR   CGD; CAL0130862; CAGL0F01023g.
DR   VEuPathDB; FungiDB:CAGL0F01023g; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   HOGENOM; CLU_006468_0_0_1; -.
DR   InParanoid; Q6FUS6; -.
DR   OMA; LDDRPIH; -.
DR   Proteomes; UP000002428; Chromosome F.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030684; C:preribosome; IEA:EnsemblFungi.
DR   GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   CDD; cd12669; RRM1_Nop12p_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034777; Nop12_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..396
FT                   /note="Nucleolar protein 12"
FT                   /id="PRO_0000081667"
FT   DOMAIN          112..220
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          228..312
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          43..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..66
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..104
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..396
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   396 AA;  45327 MW;  1D70036456F1BBD0 CRC64;
     MNLFPETVAT DDKVSQLFKT SNALDKKATP LIKVQKIEVI KKTDKDADGD EKMEDAASDD
     AKVKKPSKKK LAKKNKETKT PEQVPEEPEK LVEEGKESKK STKEDEIEKA SRTIFVGNLS
     NEVIISKSTY KLFQKLFNNI DDDDENKKLP IQSIRFRSVS FEDALPRKVA FVQQKLHKSR
     ASVNAYIVYK EQSPLLNKLI KRLNGQVFSN RHLRVDSITH PAPHDKQRSV FVGNLDFEED
     EESLWKHFGA CGSIEYVRIV RDPKTNMGKG FAYVQFNELQ SVSKALLLNE KPMISQNEHL
     KKRKLRVTRC KNIRKVEPTL KSGKYMTDGQ KTKLGRAKKI LNKAERSKLL KELTVEGIRA
     TKDDSKPVLK KGKKERSKTG RVTKRSQAFK KSQQKK