ID   NOP12_DEBHA             Reviewed;         462 AA.
AC   Q6BTS9;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Nucleolar protein 12;
GN   Name=NOP12; OrderedLocusNames=DEHA2C16170g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
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DR   EMBL; CR382135; CAG86472.2; -; Genomic_DNA.
DR   RefSeq; XP_458390.2; XM_458390.1.
DR   AlphaFoldDB; Q6BTS9; -.
DR   SMR; Q6BTS9; -.
DR   STRING; 4959.XP_458390.2; -.
DR   EnsemblFungi; CAG86472; CAG86472; DEHA2C16170g.
DR   GeneID; 2900789; -.
DR   KEGG; dha:DEHA2C16170g; -.
DR   VEuPathDB; FungiDB:DEHA2C16170g; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   HOGENOM; CLU_006468_0_0_1; -.
DR   InParanoid; Q6BTS9; -.
DR   OMA; QFHDENA; -.
DR   OrthoDB; 1176212at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12669; RRM1_Nop12p_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034777; Nop12_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..462
FT                   /note="Nucleolar protein 12"
FT                   /id="PRO_0000081668"
FT   DOMAIN          159..258
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          266..348
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          27..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..125
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..401
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..462
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  51932 MW;  C6A856B9A4991266 CRC64;
     MSTFSSIFGS SGDNANVDKS IDSLFKASKG PVSRQYSDRA RTVINIPADA ATEESGADQS
     ESIEETEEDK ERDIKAEAKR AKKTRQKKDL NEDLESKYYN KLLKEQDEEA PKVEKDEKVE
     SGSGSDSDSD DEEDQSGETK SKRAKTVDLK ENELEKAERT VFVGNVNASV VGSKPMYKKF
     KKLFSQYGKI QSIRFRSISF DDAVPRKVAF AKKKLHSSRD TLNAYVVFAE KEPSLKCVPK
     LNATEFEHAH LRVDHVAHPA PKDNKRTIFV GNLDFEEKEE TLWRYFNSKT DNDVESVRVI
     RDAKTNVGKG FALVQFKDTL SVNKSLLLND KPMSAEKKRK LRISKAKAHT KPSILSPNHI
     DNSKKAYASN KSKMSAKLSD QQRTKLGRAQ TVLNKSDRAT AGKSRNIIEG QRASKGDSIA
     GIKGLKSNRD RKIKKPRIRD RSTKFKNERD SMASELKNGP KK