ID   NOP12_GIBZE             Reviewed;         559 AA.
AC   Q4IQW0; A0A098D1J4; A0A0E0RM47; A0A1C3YHP0; A0A1I9EVF2; V6R102;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Nucleolar protein 12;
GN   Name=NOP12; ORFNames=FGRAMPH1_01T01039, FGRRES_00398, FGSG_00398;
OS   Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS   / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=229533;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX   PubMed=17823352; DOI=10.1126/science.1143708;
RA   Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA   Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA   Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA   Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA   Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA   Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA   Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA   Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT   "The Fusarium graminearum genome reveals a link between localized
RT   polymorphism and pathogen specialization.";
RL   Science 317:1400-1402(2007).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA   Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA   Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA   Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA   Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA   Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA   Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA   Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA   Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA   Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA   Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA   Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX   PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA   King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA   Hammond-Kosack K.E.;
RT   "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT   graminearum.";
RL   BMC Genomics 16:544-544(2015).
CC   -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=SCB64048.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DS231663; ESU05575.1; -; Genomic_DNA.
DR   EMBL; HG970332; SCB64048.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_011316060.1; XM_011317758.1.
DR   AlphaFoldDB; Q4IQW0; -.
DR   SMR; Q4IQW0; -.
DR   STRING; 5518.FGSG_00398P0; -.
DR   PRIDE; Q4IQW0; -.
DR   EnsemblFungi; ESU05575; ESU05575; FGSG_00398.
DR   GeneID; 23547888; -.
DR   KEGG; fgr:FGSG_00398; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   HOGENOM; CLU_006468_3_0_1; -.
DR   InParanoid; Q4IQW0; -.
DR   Proteomes; UP000070720; Chromosome 1.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12669; RRM1_Nop12p_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034777; Nop12_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..559
FT                   /note="Nucleolar protein 12"
FT                   /id="PRO_0000081670"
FT   DOMAIN          211..320
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          328..432
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          24..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          429..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..115
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..194
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..531
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        532..559
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  61542 MW;  C24138234E990F19 CRC64;
     MAKGSKGLRA SSKAVDPTLD ALFASSAGPV QAPAKSKYST LLDQKVREPA KPKVHLEEDD
     EVLSEISEEL SFEEDGPSDE DEDEDEDEEN SEQEDGSGDE QEEEESEDVD ETMKDAPVEL
     DDIIDATEDK SNKERKRKRK NDNDDLEGKY LDKVAAEEEA DRAGKRQKND ALTKTEKPAV
     DEEDAGNESD IPVHETLVKD SKASDLDKAA RTVFLANVST EAISSKSAKK TLMAHLSSVL
     EKDATPPQTI ESLRFRSVAF AGGSLPKRAA YITKSLMDST TKSANAYVVY STTAAARTAA
     TKLNGTQVLD RHLRVDSVAH PSPTDHRRCV FVGNLGFVDD ETVLNTNAEG DTTEKKKNKT
     PSDIEEGLWR TFSTQGKVEN VRVVRDSKTR VGKGFAYVQF YDANDVEAAL LLDGKKFPPM
     LPRKLRVTRA KDPRKTALAQ ERARGKHIST NGPKSTKYKH KATPEEQSMA GRTSKLLGRS
     AAVQQRHKKR PSAHGESREA EGQPAGIKGP EQFVFEGRRA SARDGLPKDL KQKKGKGKKS
     GRPQNHGTKR ASEWKKKKN