ID   NOP12_KLULA             Reviewed;         462 AA.
AC   Q6CKV6;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Nucleolar protein 12;
GN   Name=NOP12; OrderedLocusNames=KLLA0F07799g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98141.2; -; Genomic_DNA.
DR   RefSeq; XP_455433.2; XM_455433.2.
DR   AlphaFoldDB; Q6CKV6; -.
DR   SMR; Q6CKV6; -.
DR   STRING; 28985.XP_455433.2; -.
DR   EnsemblFungi; CAG98141; CAG98141; KLLA0_F07799g.
DR   GeneID; 2895061; -.
DR   KEGG; kla:KLLA0_F07799g; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   HOGENOM; CLU_006468_0_0_1; -.
DR   InParanoid; Q6CKV6; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030684; C:preribosome; IEA:EnsemblFungi.
DR   GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   CDD; cd12669; RRM1_Nop12p_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034777; Nop12_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..462
FT                   /note="Nucleolar protein 12"
FT                   /id="PRO_0000081671"
FT   DOMAIN          297..378
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          24..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          432..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..99
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..398
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  52539 MW;  E53F190AFF6FB072 CRC64;
     MSALNNLFGN SKSDAAGTSS IAALFSKPNH VDERKVKSKA RTVLTEPEQD KDEQEEENVQ
     ESASTVSEGV EKEQEEQEEQ PKKKKKKTKK NDEENDNLEV QYYSKVLGDS KSKDEPKDEP
     KDDSSDSDNE DEATAVDKSS ITGTESESAK VINLKEKELA KAERTIFIGN VPNEVITSKK
     VYKEFKKLLS KDPRSENDDH DDGEEDEEEE ESKTKDVKFN VESIRFRSIA FEEALPRKVA
     FVHQKLHKSR DSINAYAVYG SSNPVKIMCQ YLNGKVFNDH HLRVDSVTHP SPHDKRRSVF
     VGNLDFEEVE ESLWKHFEPC GDIEYVRIIR DSKTNMGKGF AYVQFKDFQS VSKALLLHEK
     KIHEGKKARK LRISRCKNMR KAQGNQSSLQ NNKLNDQQRT KLGRAKKVLG KADRAKLGEE
     LTIEGLRASK GETTPVLKRT KNRSKTGRVT KRSIAFKKQN AQ