ID   NOP12_NEUCR             Reviewed;         594 AA.
AC   Q7S2L7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Nucleolar protein 12;
GN   Name=nop-12; ORFNames=NCU09131;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
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DR   EMBL; CM002236; EAA29667.1; -; Genomic_DNA.
DR   RefSeq; XP_958903.1; XM_953810.2.
DR   AlphaFoldDB; Q7S2L7; -.
DR   SMR; Q7S2L7; -.
DR   STRING; 5141.EFNCRP00000006494; -.
DR   EnsemblFungi; EAA29667; EAA29667; NCU09131.
DR   GeneID; 3875051; -.
DR   KEGG; ncr:NCU09131; -.
DR   VEuPathDB; FungiDB:NCU09131; -.
DR   HOGENOM; CLU_006468_3_0_1; -.
DR   InParanoid; Q7S2L7; -.
DR   OMA; NAYAVYT; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12669; RRM1_Nop12p_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034777; Nop12_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..594
FT                   /note="Nucleolar protein 12"
FT                   /id="PRO_0000081672"
FT   DOMAIN          200..309
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          317..426
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          440..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          498..594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..98
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        547..562
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   594 AA;  64700 MW;  54D8A621EDDC3D6C CRC64;
     MGKTKGLVAP VKKVDPSLDA LFATSVGPAK PRPAAKYSEP LPTKSKKAPV PSKKEEDVQD
     EGDDEELSEL DEEYDSEVGI GEDDEDDEAE DNSDSEDEAV ATLEVVVEQG KVPEEDGPKR
     KRKQPDQHDN LEHKYLSKLA EDDEEPAGKR LKADEQSGEK KDTAKAEKKD DDDSESADEV
     PVHESLAPDA AQNEIEKANR TVFLSNVAVE AVTSRSAKKA LMKHMASVLD KEAKPAQKVE
     SIRFRSTAFA TAAIPKRAAY IKKSVMEATT KSTNAYVVYS TPAAARLACS KLNGTIVLDR
     HIRVDSVAHP APVDHKRCVF VGNLGFVDDE TVLQVKVDED GKEVTEKKKR TKQPMDVEEG
     LWRVFGKEGG KVESVRVVRD PVTRVGKGFA YVQFCDENAV ESAILLNGKK FPPMLPRELR
     VSRCKAPHKT LRAIEAKKLK AQGAVPETMK KGNNGKKGPG SKKSDYAPKI SAEAKTIAGR
     AEKLLGKFTA RQVIGSDKKK TFNKQDRYQA NQRRNHASGA NTEATGPRVP GAYKSPESFI
     LEGKRASAAD GKPKDLKFKG AKKNKAPNAG GGKKKTGRAA ARASKWKVQG KGKK