ID   NOP12_SCHPO             Reviewed;         438 AA.
AC   O13741;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Nucleolar protein 12;
GN   Name=nop12; ORFNames=SPAC16E8.06c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-95, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB11047.1; -; Genomic_DNA.
DR   PIR; T37786; T37786.
DR   RefSeq; NP_594218.1; NM_001019641.2.
DR   AlphaFoldDB; O13741; -.
DR   SMR; O13741; -.
DR   BioGRID; 278780; 13.
DR   STRING; 4896.SPAC16E8.06c.1; -.
DR   iPTMnet; O13741; -.
DR   MaxQB; O13741; -.
DR   PaxDb; O13741; -.
DR   PRIDE; O13741; -.
DR   EnsemblFungi; SPAC16E8.06c.1; SPAC16E8.06c.1:pep; SPAC16E8.06c.
DR   GeneID; 2542314; -.
DR   KEGG; spo:SPAC16E8.06c; -.
DR   PomBase; SPAC16E8.06c; nop12.
DR   VEuPathDB; FungiDB:SPAC16E8.06c; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   HOGENOM; CLU_006468_2_0_1; -.
DR   InParanoid; O13741; -.
DR   OMA; NAYAVYT; -.
DR   PhylomeDB; O13741; -.
DR   PRO; PR:O13741; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0003723; F:RNA binding; ISM:PomBase.
DR   GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR   CDD; cd12669; RRM1_Nop12p_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034777; Nop12_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..438
FT                   /note="Nucleolar protein 12"
FT                   /id="PRO_0000081673"
FT   DOMAIN          164..262
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          270..348
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          60..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          346..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..146
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..405
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..438
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         94
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         95
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   438 AA;  49381 MW;  3E943401F95E7C12 CRC64;
     MGETNSSLDN ENTSFVGKLS SSSNVDPTLN LLFSQSKPIP KPVAKETTVL TKKDVEVEEA
     NGVEEAAETI ESDTKEVQNI KPKSKKKKKK LNDSSDDIEG KYFEELLAEE DEEKDKDSAG
     LINDEEDKSP AKQSVLEERT SQEDVKSERE VAEKLANELE KSDKTVFVNN LPARVVTNKG
     DYKDLTKHFR QFGAVDSIRF RSLAFSEAIP RKVAFFEKKF HSERDTVNAY IVFRDSSSAR
     SALSLNGTMF MDRHLRVDSV SHPMPQDTKR CVFVGNLAFE AEEEPLWRYF GDCGSIDYVR
     IVRDPKTNLG KGFAYIQFKD TMGVDKALLL NEKKMPEGRT LRIMRAKSTK PKSITRSKRG
     DEKTRTLQGR ARKLIGKAGN ALLQQELALE GHRAKPGENP LAKKKVNKKR KERAAQWRNK
     KAESVGKKQK TAAGKKDK