NOP14_DROME
ID NOP14_DROME Reviewed; 852 AA.
AC Q9VEJ2;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Nucleolar protein 14 homolog;
DE AltName: Full=Nucleolar complex protein 14 homolog;
GN Name=l(3)07882; ORFNames=CG5824;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Has a role in the nuclear export of 40S pre-ribosomal subunit to the
CC cytoplasm (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP14 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55429.2; -; Genomic_DNA.
DR EMBL; AY119589; AAM50243.1; -; mRNA.
DR RefSeq; NP_001303435.1; NM_001316506.1.
DR RefSeq; NP_652040.2; NM_143783.3.
DR AlphaFoldDB; Q9VEJ2; -.
DR BioGRID; 70125; 1.
DR IntAct; Q9VEJ2; 4.
DR STRING; 7227.FBpp0082928; -.
DR PaxDb; Q9VEJ2; -.
DR PRIDE; Q9VEJ2; -.
DR EnsemblMetazoa; FBtr0083504; FBpp0082928; FBgn0010926.
DR EnsemblMetazoa; FBtr0347218; FBpp0312516; FBgn0010926.
DR GeneID; 46201; -.
DR KEGG; dme:Dmel_CG5824; -.
DR FlyBase; FBgn0010926; l(3)07882.
DR VEuPathDB; VectorBase:FBgn0010926; -.
DR eggNOG; KOG2147; Eukaryota.
DR GeneTree; ENSGT00390000017459; -.
DR HOGENOM; CLU_008874_1_0_1; -.
DR InParanoid; Q9VEJ2; -.
DR OMA; KSKMHKY; -.
DR OrthoDB; 950459at2759; -.
DR PhylomeDB; Q9VEJ2; -.
DR Reactome; R-DME-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 46201; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 46201; -.
DR PRO; PR:Q9VEJ2; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0010926; Expressed in eye disc (Drosophila) and 45 other tissues.
DR ExpressionAtlas; Q9VEJ2; baseline and differential.
DR Genevisible; Q9VEJ2; DM.
DR GO; GO:0030692; C:Noc4p-Nop14p complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; ISS:UniProtKB.
DR GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR InterPro; IPR007276; Nop14.
DR PANTHER; PTHR23183; PTHR23183; 1.
DR Pfam; PF04147; Nop14; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..852
FT /note="Nucleolar protein 14 homolog"
FT /id="PRO_0000252175"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 190..221
FT /evidence="ECO:0000255"
FT COILED 774..851
FT /evidence="ECO:0000255"
FT COMPBIAS 20..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..380
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 97552 MW; 5BB92281B1D4F573 CRC64;
MVAKGKKASA DAVYAKKTTR SANPFDNSTA QSSKRGNPFD VHVNKEKFKI LGRICKHDRG
MPGVSRAKAL QKRAQTLGQQ FAVKHKTNRF KDNRIGKHLS GDQLTESVMN ARYLAEKMSQ
VRSNQKAEKF NLNDDELLTH RGQTLEEIEQ YRDERSDDEE LDDEALDADF TAAAHFGGEG
DSAQDRQAAI DEMIVEQKRR KNEIAKEKDE VYDLTEKLDA NYKLLLPLVA KVTKDEQDAK
PPPDAYDKLL KEMIFEPRGS VADKLINPDE LAKQEAARLE KLENERLRRM RADGEEDEEA
SVAKPKHRSA DDLDDGYFLA GEDDEGDDTL AYDLDGNLGT HLNGKKEAVL KGDENEDDDD
KEGEEEEEED SDEESDSEVD NLSDLKESES ESEPEEAPKA SKKKAKKSAD TIPASLDTSI
PFTIKMPKTY EDFTELLSKH ATAQKAIIIE RIIKCNHPKL EGVNRENVVK LYSFLLQYLK
DLFEDASEQD IREHFQLLSK LMPYLYELTQ LNPERMSNTL LEVIKEKYEE FRKNHKMYPS
LDTLVYFKLV ANLYSTSDFR HPVVTPCFIF IQHVLSRSRV RTRQEISMGL FLVTVVLEFV
SQSKRLVPAV FNFLQGIVHM SIPKRDVEQL EITPPFERDG PLSKLLALPA NTESTKLEPQ
QLQPTDLVTQ TITPDFKVRA LDTSLLLIKE ALQLVEEHVG ACYLAQPFLA LLSRLPLESY
PEHVHQHHKD ATELAEKLAA QKMKPLAPAE KKPKALRLLE PRFEAVYDDK RRPKMSKAKE
ERAKLLHKIK REKKGAIREI RRDTSFVQML RLKQTLQSDK ERHEKVKRIY QEASVQQGEL
NELSRAKKKK KF
