ID   NOP14_KLULA             Reviewed;         837 AA.
AC   Q6CT09;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Probable nucleolar complex protein 14;
GN   Name=NOP14; OrderedLocusNames=KLLA0C16335g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Has a role in the nuclear export of 40S pre-ribosomal subunit to the
CC       cytoplasm (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP14 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01781.1; -; Genomic_DNA.
DR   RefSeq; XP_452930.1; XM_452930.1.
DR   AlphaFoldDB; Q6CT09; -.
DR   SMR; Q6CT09; -.
DR   STRING; 28985.XP_452930.1; -.
DR   EnsemblFungi; CAH01781; CAH01781; KLLA0_C16335g.
DR   GeneID; 2891936; -.
DR   KEGG; kla:KLLA0_C16335g; -.
DR   eggNOG; KOG2147; Eukaryota.
DR   HOGENOM; CLU_008874_0_0_1; -.
DR   InParanoid; Q6CT09; -.
DR   OMA; KSKMHKY; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0030692; C:Noc4p-Nop14p complex; IEA:EnsemblFungi.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0030515; F:snoRNA binding; ISS:UniProtKB.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR   InterPro; IPR007276; Nop14.
DR   PANTHER; PTHR23183; PTHR23183; 1.
DR   Pfam; PF04147; Nop14; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..837
FT                   /note="Probable nucleolar complex protein 14"
FT                   /id="PRO_0000137160"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          738..761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          815..837
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        746..761
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   837 AA;  96373 MW;  621D470741CCED2D CRC64;
     MGGSQLKNLK AALKANGLTG QTNVKKSSKK KGKSPREFDR EERQKTIERI REQFNPFDVK
     TNRNKKVGVM RESAAKLAVG KPGITKQAGE DQRKMFYEAK KSSKNRSGGV LDKRFGEKDK
     NLTSEEIMLE RFTKERQRQS STKRSLFNLD DSDGGEDENV YGEKLTHYGK SLSLEDDFDE
     GDLGLQHSDS EDFRLKQAGK RNMADQYGDE GLGDDALQEP ARKKTKAEVM QEVIAKSKFY
     KHERQKAQEK LVQDIEGLDD DFESIMSELR TLPKTKPSQT EISTSTDIAP DYDIKVKELV
     LEKRAAPADR TKTDEEIKKE YEDKQKELEQ KRLDRMNGIF NIEDQKDAGV EDLGEEFWED
     SDSEEGEYGE YIKAIPDSDD DVDFEKDNND DNEYDATSNG RPSARVIPSV PCPQIHDDLL
     NFLKSYPIEE HPSLVKRIVK TYQPKLAEGN KEKLGKFTAV LLRHILFLAE EDYSVNVKEI
     ASLQNELVSI LKTLSEKFTI PLSEDCRNII SDIQTRFKES QFYGLSPSDL VFFSVVGMLF
     STSDHYHLVI TPCLLLIAEF LEQIRFNSLQ KLIFGSILVR IAIQYQRISK RYIPELTYFL
     QTSLRSLIPS TKGETLENKE KQEDNLSIVG SDINWSKVAP SLELHSLFSE DLEKQESIKL
     SVLVNNLESI DWCITNIWKD LTAFPEIINP FKDILNVAAE VYPGTSKPKQ LVEKIEKLLK
     FQERLPLTLQ QHKPLAIPSN TPKFEENFNP DKKSYDPDKT RSELNKMKAQ LKKERKFTMK
     EIRKDTRFEA RQGIEEKKKE YADYHSKMAR IVNQISTEEG AEKNKYEREK KLRNTKR