NOP14_MOUSE
ID NOP14_MOUSE Reviewed; 860 AA.
AC Q8R3N1; Q5RL78;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Nucleolar protein 14;
DE AltName: Full=Nucleolar complex protein 14;
GN Name=Nop14; Synonyms=Nol14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and Czech II; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146 AND SER-148, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146 AND SER-148, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-146 AND SER-148, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Has a role in the nuclear export of 40S pre-ribosomal subunit to the
CC cytoplasm (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP14 family. {ECO:0000305}.
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DR EMBL; CH466524; EDL37463.1; -; Genomic_DNA.
DR EMBL; BC024998; AAH24998.1; -; mRNA.
DR EMBL; BC043043; AAH43043.1; -; mRNA.
DR CCDS; CCDS19218.1; -.
DR RefSeq; NP_083554.2; NM_029278.2.
DR AlphaFoldDB; Q8R3N1; -.
DR SMR; Q8R3N1; -.
DR BioGRID; 217464; 50.
DR STRING; 10090.ENSMUSP00000038382; -.
DR iPTMnet; Q8R3N1; -.
DR PhosphoSitePlus; Q8R3N1; -.
DR EPD; Q8R3N1; -.
DR jPOST; Q8R3N1; -.
DR MaxQB; Q8R3N1; -.
DR PaxDb; Q8R3N1; -.
DR PeptideAtlas; Q8R3N1; -.
DR PRIDE; Q8R3N1; -.
DR ProteomicsDB; 252991; -.
DR Antibodypedia; 22420; 74 antibodies from 19 providers.
DR Ensembl; ENSMUST00000041364; ENSMUSP00000038382; ENSMUSG00000036693.
DR GeneID; 75416; -.
DR KEGG; mmu:75416; -.
DR UCSC; uc008xcx.1; mouse.
DR CTD; 8602; -.
DR MGI; MGI:1922666; Nop14.
DR VEuPathDB; HostDB:ENSMUSG00000036693; -.
DR eggNOG; KOG2147; Eukaryota.
DR GeneTree; ENSGT00390000017459; -.
DR HOGENOM; CLU_008874_1_1_1; -.
DR InParanoid; Q8R3N1; -.
DR OMA; KSKMHKY; -.
DR OrthoDB; 950459at2759; -.
DR PhylomeDB; Q8R3N1; -.
DR TreeFam; TF105698; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 75416; 22 hits in 73 CRISPR screens.
DR ChiTaRS; Nop14; mouse.
DR PRO; PR:Q8R3N1; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8R3N1; protein.
DR Bgee; ENSMUSG00000036693; Expressed in embryonic post-anal tail and 255 other tissues.
DR ExpressionAtlas; Q8R3N1; baseline and differential.
DR Genevisible; Q8R3N1; MM.
DR GO; GO:0030692; C:Noc4p-Nop14p complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0030515; F:snoRNA binding; ISS:UniProtKB.
DR GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR InterPro; IPR007276; Nop14.
DR PANTHER; PTHR23183; PTHR23183; 1.
DR Pfam; PF04147; Nop14; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..860
FT /note="Nucleolar protein 14"
FT /id="PRO_0000137156"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..381
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 148
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 346
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P78316"
FT CONFLICT 18
FT /note="A -> T (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 239
FT /note="D -> N (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="D -> E (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 489
FT /note="T -> I (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 503
FT /note="V -> M (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 520
FT /note="I -> L (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 660
FT /note="T -> A (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 693
FT /note="S -> L (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 715
FT /note="F -> V (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 723
FT /note="S -> A (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 736
FT /note="Q -> K (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
FT CONFLICT 749
FT /note="Q -> L (in Ref. 1; AAH24998)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 860 AA; 98769 MW; A30767F90C65F6AF CRC64;
MGKAKRTGAR RQVHKAPAGA SGGPAKTNPN PFEVKVNRQK FQILGRKTRH DVGLPGVSRA
RAIRKRTQTL LKEYKERNKS NVFADKRFGE YNSNISPEEK MMKRFALEQQ RYHEKKNIYN
LNEDEELTHY GQSLADIEKH NDIVDSDSDT EDRGALSAEL TASHFGGGVH KNSSQKEGED
GDKPKTRKEL IEELIAKSKQ EKRERQAQRE DALELTEKLD QDWKEIQILM SRKPKKSEDK
EKKEKPQPDE YDMMVRELGF EMKAQPSNRM KTEEELAKEE QERLKKLEAE RLRRMLGKDE
HENKKKPKHT SADDLNDGFI LDKDDRRLLS YKDGKMNIED VQEEQSKEAD GQENDQKEGE
DDSEEEDESH EDSEESEDPD SHSDLESNIE SEEENETPKK EQRQTPGGKL PKDDQKAQKA
VAAELPYVFA APESFEELKF LLSGRSMEEQ LLVVERIQKC NHPSLAVGNK AKLEKLFGFL
LQYIGDLATD STPDLKTIDK LVVHLYSLCQ MFPESASDSI RFVLRDAMHE MEEMIETKGR
AAFPGLDVLI YLKITGLLFP TSDFWHPVVT PALLCMSQML TKCPVMSLQD VIKGLFVCCL
FLEYVSLSRR FIPELFNFLL GILYIATPNT KSQGSTLVHP FRALGKNSEL LVVSDKADVT
TWQRGSLPLH WANRLSTLTA TEANHTRLSC VASCLSLMKH CVLMYQALPS FHAIFRPHQA
LLSKHLADCS LPQELQELAQ SILSAMEGQK QHCRPLVCEK SKPVPLKQFT PRLVKVLEFG
RKQGSSKEEQ ERKRLIHKHK REFKGAVREI RKDNQFLARM QLSEIMERDA ERKRKVKQLF
NSLATQEGEW KALKRKKFKK
