NOP14_SCHPO
ID NOP14_SCHPO Reviewed; 827 AA.
AC O43051;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Probable nucleolar complex protein 14;
GN Name=nop14; ORFNames=SPBC3F6.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Has a role in the nuclear export of 40S pre-ribosomal subunit to the
CC cytoplasm (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP14 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA17693.1; -; Genomic_DNA.
DR PIR; T40394; T40394.
DR RefSeq; NP_596742.1; NM_001023762.2.
DR AlphaFoldDB; O43051; -.
DR SMR; O43051; -.
DR BioGRID; 277199; 4.
DR STRING; 4896.SPBC3F6.04c.1; -.
DR iPTMnet; O43051; -.
DR MaxQB; O43051; -.
DR PaxDb; O43051; -.
DR PRIDE; O43051; -.
DR EnsemblFungi; SPBC3F6.04c.1; SPBC3F6.04c.1:pep; SPBC3F6.04c.
DR GeneID; 2540674; -.
DR KEGG; spo:SPBC3F6.04c; -.
DR PomBase; SPBC3F6.04c; nop14.
DR VEuPathDB; FungiDB:SPBC3F6.04c; -.
DR eggNOG; KOG2147; Eukaryota.
DR HOGENOM; CLU_008874_0_0_1; -.
DR InParanoid; O43051; -.
DR OMA; KSKMHKY; -.
DR PhylomeDB; O43051; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O43051; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030692; C:Noc4p-Nop14p complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0030515; F:snoRNA binding; ISS:UniProtKB.
DR GO; GO:0030490; P:maturation of SSU-rRNA; ISO:PomBase.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR InterPro; IPR007276; Nop14.
DR PANTHER; PTHR23183; PTHR23183; 1.
DR Pfam; PF04147; Nop14; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..827
FT /note="Probable nucleolar complex protein 14"
FT /id="PRO_0000137161"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..376
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 190
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 827 AA; 95152 MW; 8E1EFDCF204D70BF CRC64;
MGKNGSQLKN LKSSIRQANL GTRPNNKKSR TRSTESHEDR QAKVQKIQSD FNLFDRQFTK
RKFDVGGRRV KGTEGKPGVS RGVGEELRRR TIGAELKKRN RSGAIIDRRF GENNPHLSVE
EKMLERFSRE QQRRSKRELY NLDAEDVLTH GNRPLSDIDS FEEPGFGLDE GEELNDEVVR
RMHFGGFEDS DAENEKEGEG AHKSKREVMS EIIAKSKHYK AERQAEKERY EDEREKLDEQ
MEDLQSFLSD YKKASRKSGI KTQRPIISDG DARYDSFVRE MVFDKRAHPT ERTKTEEELA
QIEADRLREL EDQRISRMEH YQEDSASEAG SIEDEQATDN VFGFGKGLEQ ENEEEWNGIN
EEAEESEDEE SVNSDTSFVD DEQLKVEEQP LVGSAIKNEG SEKASLAYTY PCPTSHVEFV
QLLKGLDYKD YPTVVSRIRT LHHVKLHPDN KSRLENFSVI LLQHILHLTR QPMISMELLE
HLTEHLHSLA QQFPSALGIS FISVVEGMRK RLAKSYVYPE IKFPEISDLL FFNLTGSIFP
TSDKKHIVVS PVMLTMAESL SQSPADSLSD VCKKLYIANL FLKFQSYSHR YVPEVITAVS
QALYLLYPNF ISIVPGTFAL PDSLKEKQNL FAIQDISLDE PQRLSLYELE ELPTGLLQSS
ILFITLNLIE MAIDIYFKEQ AFIEIFVPIM DMLQLYSLKK ELLSKRLSEK LLSTLQAVSD
SIESAKANRK PLALQSHRPL GITSQVPKFE EGYSLDKSSH DIDPERAQLN KLRAQHRDAK
KGAIRTLRKD ARFIARERRQ EQRAKDQAYN EKMRKLENRL QHFDPAV
