NOP16_MOUSE
ID NOP16_MOUSE Reviewed; 178 AA.
AC Q9CPT5; Q8C2P2; Q921K0;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Nucleolar protein 16;
GN Name=Nop16; Synonyms=D13Wsu177e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-7 AND ARG-71.
RC STRAIN=C57BL/6J, and NOD; TISSUE=Kidney, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP16 family. {ECO:0000305}.
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DR EMBL; AK002696; BAB22290.1; -; mRNA.
DR EMBL; AK013251; BAB28746.1; -; mRNA.
DR EMBL; AK088248; BAC40235.1; -; mRNA.
DR EMBL; BC012213; AAH12213.1; -; mRNA.
DR CCDS; CCDS26531.1; -.
DR RefSeq; NP_848720.1; NM_178605.4.
DR AlphaFoldDB; Q9CPT5; -.
DR SMR; Q9CPT5; -.
DR BioGRID; 205775; 10.
DR IntAct; Q9CPT5; 3.
DR MINT; Q9CPT5; -.
DR STRING; 10090.ENSMUSP00000026987; -.
DR iPTMnet; Q9CPT5; -.
DR PhosphoSitePlus; Q9CPT5; -.
DR EPD; Q9CPT5; -.
DR MaxQB; Q9CPT5; -.
DR PaxDb; Q9CPT5; -.
DR PeptideAtlas; Q9CPT5; -.
DR PRIDE; Q9CPT5; -.
DR ProteomicsDB; 293702; -.
DR Ensembl; ENSMUST00000026987; ENSMUSP00000026987; ENSMUSG00000025869.
DR GeneID; 28126; -.
DR KEGG; mmu:28126; -.
DR UCSC; uc007qok.1; mouse.
DR CTD; 51491; -.
DR MGI; MGI:107862; Nop16.
DR VEuPathDB; HostDB:ENSMUSG00000025869; -.
DR eggNOG; KOG4706; Eukaryota.
DR GeneTree; ENSGT00390000003426; -.
DR HOGENOM; CLU_115103_0_0_1; -.
DR InParanoid; Q9CPT5; -.
DR OMA; MRSVKHG; -.
DR OrthoDB; 1431164at2759; -.
DR PhylomeDB; Q9CPT5; -.
DR TreeFam; TF323541; -.
DR BioGRID-ORCS; 28126; 27 hits in 77 CRISPR screens.
DR ChiTaRS; Nop16; mouse.
DR PRO; PR:Q9CPT5; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9CPT5; protein.
DR Bgee; ENSMUSG00000025869; Expressed in ileal epithelium and 262 other tissues.
DR ExpressionAtlas; Q9CPT5; baseline and differential.
DR Genevisible; Q9CPT5; MM.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR InterPro; IPR019002; Ribosome_biogenesis_Nop16.
DR PANTHER; PTHR13243; PTHR13243; 1.
DR Pfam; PF09420; Nop16; 2.
PE 1: Evidence at protein level;
KW Acetylation; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..178
FT /note="Nucleolar protein 16"
FT /id="PRO_0000250158"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 8
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3C1"
FT MOD_RES 90
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3C1"
FT MOD_RES 144
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3C1"
FT CROSSLNK 74
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3C1"
FT VARIANT 7
FT /note="K -> R (in strain: NOD)"
FT /evidence="ECO:0000269|PubMed:16141072"
FT VARIANT 71
FT /note="K -> R (in strain: NOD)"
FT /evidence="ECO:0000269|PubMed:16141072"
FT CONFLICT 155
FT /note="Y -> S (in Ref. 2; AAH12213)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 178 AA; 21139 MW; F93BBDF17A0FF9BA CRC64;
MPKAKGKTRR QKFGYNVNRK RLNRNARRKA APRIECSHIR HAWDHTKSVR QNLAEMGLAM
DPNKAVPLRK KKVKAMEVDT EERPRDLVRK PYVVNDLEAE ASLPEKKGNT LSRDLIDYVR
YMVENHGEDY KAMARDEKNY YQDTPKQIRN KINVYKRFYP TEWQAFIDSL QSKKMEVD
