ID   NOP53_CAEEL             Reviewed;         438 AA.
AC   Q9NEU5;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Ribosome biogenesis protein NOP53 {ECO:0000305};
GN   ORFNames=Y39B6A.33 {ECO:0000312|WormBase:Y39B6A.33};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=24556985; DOI=10.1073/pnas.1400705111;
RA   Yoon J.C., Ling A.J., Isik M., Lee D.Y., Steinbaugh M.J., Sack L.M.,
RA   Boduch A.N., Blackwell T.K., Sinclair D.A., Elledge S.J.;
RT   "GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:3781-3786(2014).
CC   -!- FUNCTION: May play a role in ribosome biogenesis, being required for
CC       integration of the 5S RNP into the ribosomal large subunit.
CC       {ECO:0000250|UniProtKB:Q9NZM5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NZM5}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q9NZM5}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated inactivation of the gene induces
CC       lower oxygen consumption rate of the worms.
CC       {ECO:0000269|PubMed:24556985}.
CC   -!- SIMILARITY: Belongs to the NOP53 family. {ECO:0000305}.
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DR   EMBL; AL132948; CAC51048.1; -; Genomic_DNA.
DR   PIR; T45041; T45041.
DR   RefSeq; NP_741664.1; NM_171574.4.
DR   AlphaFoldDB; Q9NEU5; -.
DR   BioGRID; 45208; 7.
DR   STRING; 6239.Y39B6A.33; -.
DR   EPD; Q9NEU5; -.
DR   PaxDb; Q9NEU5; -.
DR   PeptideAtlas; Q9NEU5; -.
DR   EnsemblMetazoa; Y39B6A.33.1; Y39B6A.33.1; WBGene00012692.
DR   UCSC; Y39B6A.33; c. elegans.
DR   WormBase; Y39B6A.33; CE21690; WBGene00012692; -.
DR   eggNOG; KOG2823; Eukaryota.
DR   GeneTree; ENSGT00390000017267; -.
DR   HOGENOM; CLU_050123_0_0_1; -.
DR   InParanoid; Q9NEU5; -.
DR   OMA; WEKVTTE; -.
DR   OrthoDB; 1025498at2759; -.
DR   PhylomeDB; Q9NEU5; -.
DR   PRO; PR:Q9NEU5; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00012692; Expressed in larva and 4 other tissues.
DR   GO; GO:0005730; C:nucleolus; HDA:WormBase.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0008097; F:5S rRNA binding; IBA:GO_Central.
DR   GO; GO:1901857; P:positive regulation of cellular respiration; IMP:WormBase.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR011687; Nop53/GLTSCR2.
DR   PANTHER; PTHR14211; PTHR14211; 1.
DR   Pfam; PF07767; Nop53; 1.
DR   PIRSF; PIRSF017302; Gltscr2; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..438
FT                   /note="Ribosome biogenesis protein NOP53"
FT                   /id="PRO_0000218961"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   438 AA;  49746 MW;  36FF07DABD978197 CRC64;
     MVAGKRTGAA KGSRHNKKYW RKGTNIDDIE DSIHIKSRQA ATGGVISEMK DEDLFIVDRT
     ATANKPVVPK LTKKQQAALE KITKNITQEH VTLPKPSTTS KILKKPAKLP RGNAILALKK
     GPKAAAPAAK KKNFDVWTTD LTPKIPKSKL ENQEAAEHFL KVVKKKQPKT PGKSITSLLP
     AVQIAEGGAS YNPESAEYQE YVAKIAGEEQ KLIDHEAKIK AGIEPQWEKV TTEHERFLEM
     AEGLRIHPKY GKDDEEEEEA GNSEKSMKTG GEAEPKSQRV ECDRMTKEQK KKKAKAQKLD
     KEEKRRLEEK AKEQDSHNVY RTKQLHKELD EEEKQRHEES EVRKKEKLIN KLTKRQQLGK
     GKFVDAEDPF LLQEELTGNL RQLKPQGHVL DDRMKSLQRR NMLPIGGDKE KRRIKNRLKS
     KVVEKRSAKN IVKGSRVI