NOP53_DROME
ID NOP53_DROME Reviewed; 478 AA.
AC Q9W3C2;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Ribosome biogenesis protein NOP53 {ECO:0000305};
GN ORFNames=CG1785 {ECO:0000312|EMBL:AAK92942.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: May play a role in ribosome biogenesis, being required for
CC integration of the 5S RNP into the ribosomal large subunit.
CC {ECO:0000250|UniProtKB:Q9NZM5}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9NZM5}. Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:Q9NZM5}.
CC -!- SIMILARITY: Belongs to the NOP53 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF46409.1; -; Genomic_DNA.
DR EMBL; AY051518; AAK92942.1; -; mRNA.
DR RefSeq; NP_572502.1; NM_132274.3.
DR AlphaFoldDB; Q9W3C2; -.
DR SMR; Q9W3C2; -.
DR BioGRID; 58269; 5.
DR DIP; DIP-22782N; -.
DR IntAct; Q9W3C2; 9.
DR STRING; 7227.FBpp0071193; -.
DR PaxDb; Q9W3C2; -.
DR PRIDE; Q9W3C2; -.
DR DNASU; 31810; -.
DR EnsemblMetazoa; FBtr0071250; FBpp0071193; FBgn0030061.
DR GeneID; 31810; -.
DR KEGG; dme:Dmel_CG1785; -.
DR UCSC; CG1785-RA; d. melanogaster.
DR FlyBase; FBgn0030061; CG1785.
DR VEuPathDB; VectorBase:FBgn0030061; -.
DR eggNOG; KOG2823; Eukaryota.
DR GeneTree; ENSGT00390000017267; -.
DR HOGENOM; CLU_035888_0_1_1; -.
DR InParanoid; Q9W3C2; -.
DR OMA; WRKTDIQ; -.
DR OrthoDB; 1025498at2759; -.
DR PhylomeDB; Q9W3C2; -.
DR BioGRID-ORCS; 31810; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31810; -.
DR PRO; PR:Q9W3C2; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030061; Expressed in eye disc (Drosophila) and 51 other tissues.
DR Genevisible; Q9W3C2; DM.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0008097; F:5S rRNA binding; IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; ISS:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR011687; Nop53/GLTSCR2.
DR PANTHER; PTHR14211; PTHR14211; 1.
DR Pfam; PF07767; Nop53; 1.
DR PIRSF; PIRSF017302; Gltscr2; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..478
FT /note="Ribosome biogenesis protein NOP53"
FT /id="PRO_0000218962"
FT REGION 90..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 55788 MW; 12A1EEF57366F618 CRC64;
MTAVEPATKK KRISKKNKSA WRKTDIQDVE QFLEDQRQEE RVGTFADKQD EDLFVVDSSL
PKTKATVLSV KQKRKLNAKK PMRSYQALEN TSKVQDPIAK RNHVRQKKNG RNIELEVCNP
TKPRHRQANS DRAQYYVKLE QRLADKKNKK LDVEKDIWQE VDFRDEIPGL KDEKGWISRE
LALHTAGNIG KKVVKTHASL HHKTTKAKKF ELPHPGMSYN PAPEDHQALI DQVVEREEGI
IKKEQHLKRV TTSMFSKVTP EERDRRRLNE MSQGMDEEEG SELDEDVQTN GKKKEDDDEK
PYHTINAPVE NKKKSKQARR NELKQKELAR QTELKRKLKQ QTADLIRIKS IRHELDDEEE
DLNDLKKRRK QRAEKAKFEP KRLGRHKFEE PDLDVNLPED IAGNLRNVKT ESSLLKDRFH
TLQRNNMLPT TKLVSRKKSK VKRFERNSHK EPGVSYNDLK ERRRAAAAAA KATANIKI
