NOP53_SCHPO
ID NOP53_SCHPO Reviewed; 419 AA.
AC Q9UUI4;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Ribosome biogenesis protein NOP53 {ECO:0000305};
GN Name=rrp16 {ECO:0000312|PomBase:SPAC22F8.09};
GN Synonyms=nop53 {ECO:0000312|PomBase:SPAC22F8.09};
GN ORFNames=SPAC22F8.09 {ECO:0000312|PomBase:SPAC22F8.09};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242; SER-249; SER-252 AND
RP SER-256, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: May play a role in ribosome biogenesis.
CC {ECO:0000250|UniProtKB:Q12080}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q12080}. Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:Q12080}.
CC -!- SIMILARITY: Belongs to the NOP53 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB52719.1; -; Genomic_DNA.
DR PIR; T38199; T38199.
DR RefSeq; NP_594732.1; NM_001020160.2.
DR AlphaFoldDB; Q9UUI4; -.
DR SMR; Q9UUI4; -.
DR BioGRID; 278176; 23.
DR STRING; 4896.SPAC22F8.09.1; -.
DR iPTMnet; Q9UUI4; -.
DR MaxQB; Q9UUI4; -.
DR PaxDb; Q9UUI4; -.
DR PRIDE; Q9UUI4; -.
DR EnsemblFungi; SPAC22F8.09.1; SPAC22F8.09.1:pep; SPAC22F8.09.
DR GeneID; 2541680; -.
DR KEGG; spo:SPAC22F8.09; -.
DR PomBase; SPAC22F8.09; rrp16.
DR VEuPathDB; FungiDB:SPAC22F8.09; -.
DR eggNOG; KOG2823; Eukaryota.
DR HOGENOM; CLU_035888_1_0_1; -.
DR InParanoid; Q9UUI4; -.
DR OMA; WRKTDIQ; -.
DR PhylomeDB; Q9UUI4; -.
DR PRO; PR:Q9UUI4; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0008097; F:5S rRNA binding; IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; ISS:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR011687; Nop53/GLTSCR2.
DR PANTHER; PTHR14211; PTHR14211; 1.
DR Pfam; PF07767; Nop53; 1.
DR PIRSF; PIRSF017302; Gltscr2; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..419
FT /note="Ribosome biogenesis protein NOP53"
FT /id="PRO_0000218964"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 242
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 249
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 252
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 419 AA; 48130 MW; 9C2A72E639E61DAA CRC64;
MGIKERNAPS QYKQSSRKNK RAWRKNIDLE DIESGLEQTR DEEIKGGNVE HKPNDALFVI
DTLGDDRIAK RSRKKIKPLK VDQILENKSS IEKVHSHLTN NSTESNKKGK IFSRKELNRL
QALVYKNKDG LTATSAASEL KNTKQPKESY DVWETNPTVT IPVKRPSTLS KLPESLTENN
AKVPNVVIAD PGMSYNPDAA AWMKLLDTKG SEELKKEQKR ISELEEKERI QKKAFEDKGL
VSDQDVNHSI DSDDQSEHEQ AETPIPSSKN KRKTRSQRNK IRQRREEELR LLEQKKNEEL
LRTIDKAPAI SKKLQQKDKA EKFSNKAVSS STTEIKLKKK KFGKHRLPNN PLEIKLGDEL
TSSLRELKPE GNLFADRYLS LQQRAMVPPS LPVLKKSKYR AKIKEKYSHK DFHLQKNSI
