NOP56_BOVIN
ID NOP56_BOVIN Reviewed; 596 AA.
AC Q3SZ63;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Nucleolar protein 56;
DE AltName: Full=Nucleolar protein 5A;
GN Name=NOP56; Synonyms=NOL5A;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the early to middle stages of 60S ribosomal
CC subunit biogenesis. Core component of box C/D small nucleolar
CC ribonucleoprotein (snoRNP) particles. Required for the biogenesis of
CC box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Part of a large pre-ribosomal ribonucleoprotein (RNP) complex,
CC that consists of at least 62 ribosomal proteins, 45 nonribosomal
CC proteins and both pre-rRNA and mature rRNA species. Within this complex
CC directly interacts with TCOF1 in an RNA-independent manner. Core
CC component of box C/D small nucleolar ribonucleoprotein (snoRNP)
CC particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble
CC stepwise onto the snoRNA. Interacts NOP1 and NOP58. Interacts with
CC NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association
CC of NOP56 with NUFIP1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm
CC {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR EMBL; BC103114; AAI03115.1; -; mRNA.
DR RefSeq; NP_001028794.1; NM_001033622.2.
DR AlphaFoldDB; Q3SZ63; -.
DR SMR; Q3SZ63; -.
DR STRING; 9913.ENSBTAP00000025042; -.
DR PaxDb; Q3SZ63; -.
DR PRIDE; Q3SZ63; -.
DR GeneID; 404165; -.
DR KEGG; bta:404165; -.
DR CTD; 10528; -.
DR eggNOG; KOG2573; Eukaryota.
DR InParanoid; Q3SZ63; -.
DR OrthoDB; 632707at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.246.90; -; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR012974; NOP5_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; PTHR10894; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; SSF89124; 1.
DR PROSITE; PS51358; NOP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Isopeptide bond; Methylation; Nucleus;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW Ubl conjugation.
FT CHAIN 1..596
FT /note="Nucleolar protein 56"
FT /id="PRO_0000246078"
FT DOMAIN 292..410
FT /note="Nop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT REGION 458..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 314
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 359
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 465
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D6Z1"
FT MOD_RES 466
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D6Z1"
FT MOD_RES 510
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 518
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 519
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 536
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D6Z1"
FT MOD_RES 560
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9D6Z1"
FT MOD_RES 562
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 569
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 570
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 581
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 583
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 87
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 230
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 240
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 539
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 564
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
SQ SEQUENCE 596 AA; 66331 MW; 74D35A9E6B5DD0B6 CRC64;
MVLLHVLFEH AVGYALLALK EVEEIILLLP QVEECVLNLG KFHNIVRLVA FCPFSSSQVA
LENANAVSEG VVHEDLRLLL ETHLPPKKKK VLLGVGDPKI GAAIQEELGY NCQTGGVIAE
ILRGVRLHFH NLVKGLTDLS ACKAQLGLGH SYSRAKVKFN VNRVDNMIIQ SISLLDQLDK
DINTFSMRVR EWYGYHFPEL VKIINDNATY CRLAQFIGNR KELNEEKLEK LEELTMDAAK
AKAILDASRS SMGMDISAID LINIESFSSR VVSLSEYRQS LHTYLRSKMS QVAPSLSALI
GEAVGARLIA HAGSLTNLAK YPASTVQILG AEKALFRALK TRGNTPKYGL IFHSTFIGRA
AAKNKGRISR YLANKCSIAS RIDCFSEVPT SVFGEKLREQ VEERLSFYET GEIPRKNLDV
MKEAMVQAEE AAAEITRKLE KQEKKRLKKE KKRLAAIALA SSENSSAPEE CEETSERPKK
KKKQKPQEVL QENGMEDPSV SFSKPKKKKS FSKEELVSSD LEETAGTGSL PKRKKSFPKE
EPVTDPDESE NKRVPKKKRK LSPKEEPLSS GPEEAAASKS SGSKKKKKLR KLSQES
