ID   NOP56_DICDI             Reviewed;         540 AA.
AC   Q54MT2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Nucleolar protein 56;
DE   AltName: Full=Nucleolar protein 5A;
GN   Name=nop56; Synonyms=nol5a; ORFNames=DDB_G0285679;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for 60S ribosomal subunit biogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; AAFI02000079; EAL64677.1; -; Genomic_DNA.
DR   RefSeq; XP_638211.1; XM_633119.1.
DR   AlphaFoldDB; Q54MT2; -.
DR   SMR; Q54MT2; -.
DR   STRING; 44689.DDB0237576; -.
DR   PaxDb; Q54MT2; -.
DR   EnsemblProtists; EAL64677; EAL64677; DDB_G0285679.
DR   GeneID; 8625259; -.
DR   KEGG; ddi:DDB_G0285679; -.
DR   dictyBase; DDB_G0285679; nol5a.
DR   eggNOG; KOG2573; Eukaryota.
DR   HOGENOM; CLU_015495_5_2_1; -.
DR   InParanoid; Q54MT2; -.
DR   OMA; VDHHEEY; -.
DR   PhylomeDB; Q54MT2; -.
DR   Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q54MT2; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:dictyBase.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISS:dictyBase.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..540
FT                   /note="Nucleolar protein 56"
FT                   /id="PRO_0000331208"
FT   DOMAIN          291..408
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          434..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        434..535
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   540 AA;  60800 MW;  0F48391CB55A35B5 CRC64;
     MATHILFETA TGFNIFQLSG MESIAEFTDQ VQKSMQDFSK FSKVCKMVGS LPFTSAENAL
     ENINSISEGI LTESLHDFLK QTFSKKTEGV VLGVCDNKLS ASIGDELKIS CLSNSHTSEI
     IRCIRNHISE FTKLKSADLL KAQLGLGHSY SRSKVKFNVH KVDNMIIQSI CLLEQLDKDL
     NTFFMRLREW YSWHFPELLK IIESQVHFAK LAKLIQNKKN LTEESLDEIK EILEDNESLA
     KDVLSAAKAS MGGDISQIDL VTVMHFADRV ISLDEYRTNL TQYLAKKMQD IAPNLSALVG
     DRIGAKLISR AGSLTSLAKY PASTVQILGA EKALFRAMKV RGKTPKYGII FNASAVSSET
     KNKGRIARCL SNKISIATRI DCFSDNPTAK FGVALKQQVA DRIKFFNNGV APKRNLDVMK
     EVIEEVEKDF AEEEVKPVVK ESSSKKRKES EPTEEKSSKK SKKEEKSSKK SKSDDVEMKE
     EPVKEEKKSS KKSSSKKEEE PVKEEKKSSS KKEDKKEKKE SKKDEKEEKK SSKKDKKEKK