NOP56_PONAB
ID NOP56_PONAB Reviewed; 594 AA.
AC Q5RA29;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Nucleolar protein 56;
DE AltName: Full=Nucleolar protein 5A;
GN Name=NOP56; Synonyms=NOL5A;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the early to middle stages of 60S ribosomal
CC subunit biogenesis. Core component of box C/D small nucleolar
CC ribonucleoprotein (snoRNP) particles. Required for the biogenesis of
CC box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Part of a large pre-ribosomal ribonucleoprotein (RNP) complex,
CC that consists of at least 62 ribosomal proteins, 45 nonribosomal
CC proteins and both pre-rRNA and mature rRNA species. Within this complex
CC directly interacts with TCOF1 in an RNA-independent manner. Core
CC component of box C/D small nucleolar ribonucleoprotein (snoRNP)
CC particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble
CC stepwise onto the snoRNA. Interacts NOP1 and NOP58. Interacts with
CC NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association
CC of NOP56 with NUFIP1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm
CC {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR EMBL; CR859194; CAH91381.1; -; mRNA.
DR RefSeq; NP_001125816.1; NM_001132344.2.
DR AlphaFoldDB; Q5RA29; -.
DR SMR; Q5RA29; -.
DR STRING; 9601.ENSPPYP00000012104; -.
DR PRIDE; Q5RA29; -.
DR GeneID; 100172744; -.
DR KEGG; pon:100172744; -.
DR CTD; 10528; -.
DR eggNOG; KOG2573; Eukaryota.
DR InParanoid; Q5RA29; -.
DR OrthoDB; 632707at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.246.90; -; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR012974; NOP5_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; PTHR10894; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; SSF89124; 1.
DR PROSITE; PS51358; NOP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Isopeptide bond; Methylation; Nucleus;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW Ubl conjugation.
FT CHAIN 1..594
FT /note="Nucleolar protein 56"
FT /id="PRO_0000219028"
FT DOMAIN 292..410
FT /note="Nop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT REGION 457..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 314
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 359
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 466
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D6Z1"
FT MOD_RES 467
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D6Z1"
FT MOD_RES 468
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9D6Z1"
FT MOD_RES 511
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 519
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 520
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 537
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D6Z1"
FT MOD_RES 561
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9D6Z1"
FT MOD_RES 563
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 569
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 570
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 579
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT MOD_RES 581
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 87
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 230
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 240
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 540
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
FT CROSSLNK 564
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O00567"
SQ SEQUENCE 594 AA; 65947 MW; 682C8AE02A168764 CRC64;
MVLLHVLFEH AVGYALLALK EVEEISLLQP QVEESVLNLG KFHNIVRLVA FCPFASSQVA
LENANAVSEG VVHEDLRLLL ETHLPSKKKR VLLGVGDPKI GAAIQEELGY NCQTGGVIAE
ILRGVRLHFH NLVKGLTDLS ACKAQLGLGH SYSRTKVKFN VNRVDNMIIQ SISLLDQLDK
DINTFSMRVR EWYGYHFPEL VKIINDNATY CRLAQFIGNR RELNEDKLEK LEELTMDGAK
AKAILDASRS SMGMDISAID LINIESFSSR VVSLSEYRQS LHTYLRSKMS QVAPSLSALI
GEAVGARLIA HAGSLTNLAK YPASTVQILG AEKALFRALK TRGNTPKYGL IFHSTFIGRA
AAKNKGRISR YLANKCSIAS RIDCFSEVPT SVFGEKLREQ VEERLSFYET GEIPRKNLDV
MKEAMVQAEE AAAEITRKLE KQEKKRLKKE KKRLAALALA SSENSSSTPE ECEETSEKPK
KKKKQKPQEV PQENGMEDPS ISFSKPKKKK SFSKEELMSS DPEETAGSTS IPKKKKSSPK
GETVNDPEEA GHRSGSKKKR KFSKEEPVSS GPEEAAGKSS SKKKKKFHKA SQED
