ID   NOP56_SCHPO             Reviewed;         497 AA.
AC   O94514;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Nucleolar protein 56;
DE   AltName: Full=Ribosome biosynthesis protein sik1;
GN   Name=nop56; Synonyms=sik1; ORFNames=SPBC646.10c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Required for 60S ribosomal subunit synthesis. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA22814.1; -; Genomic_DNA.
DR   PIR; T40586; T40586.
DR   RefSeq; NP_595368.1; NM_001021276.2.
DR   AlphaFoldDB; O94514; -.
DR   SMR; O94514; -.
DR   BioGRID; 277602; 17.
DR   IntAct; O94514; 1.
DR   STRING; 4896.SPBC646.10c.1; -.
DR   iPTMnet; O94514; -.
DR   MaxQB; O94514; -.
DR   PaxDb; O94514; -.
DR   PRIDE; O94514; -.
DR   EnsemblFungi; SPBC646.10c.1; SPBC646.10c.1:pep; SPBC646.10c.
DR   GeneID; 2541087; -.
DR   KEGG; spo:SPBC646.10c; -.
DR   PomBase; SPBC646.10c; nop56.
DR   VEuPathDB; FungiDB:SPBC646.10c; -.
DR   eggNOG; KOG2573; Eukaryota.
DR   HOGENOM; CLU_015495_4_0_1; -.
DR   InParanoid; O94514; -.
DR   OMA; DNYMFAK; -.
DR   PhylomeDB; O94514; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:O94514; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0030532; C:small nuclear ribonucleoprotein complex; ISO:PomBase.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis.
FT   CHAIN           1..497
FT                   /note="Nucleolar protein 56"
FT                   /id="PRO_0000337263"
FT   DOMAIN          295..413
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          448..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..465
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..489
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   497 AA;  55388 MW;  27F94313F72AB987 CRC64;
     MADYLLYESA TGYSLFDVVG ADQIAAKTKE VQLSLQDISK FGKVVQLRSF IPFKNAAHAL
     ENANDISEGV LNDFLKNFLE LNLPKASKKK KVSLGVQDKN LATSIKSEID AIECDTSELT
     QDLLRGIRFH GDKLLKQLSP GDFERAQLGL GHSYSRAKVK FNVNRNDNMI IQAIAILDQL
     DKDINTFAMR MKEWYSWHFP ELSKIVGDNY KYAVIVTLVG DKTTINDEML HDLAAVVDDD
     KDIAQSIINA GKVSMGQDIS EIDLENILSF AERVIKLSNY RKQLHNYLVQ KMNVVAPNLA
     ELIGEMVGAR LISHAGSLTN LSKCPASTVQ ILGAEKALFR ALKTRGNTPK YGIIYHSSFI
     GKAGAKNKGR ISRFLANKCS IASRIDNFSD APTTAFGQVL RRQVEERLNF FDTGVAPTRN
     SIAMAEAYEK ALSSVNIDGD EEVDIDVEET VETISEKPSK KEKKDKKEKK KEKSKKKRSA
     DDASEEVKKS KKKKKSH