ID   NOP58_AJECN             Reviewed;         635 AA.
AC   A6QYH8;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Nucleolar protein 58;
GN   Name=NOP58; ORFNames=HCAG_02435;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; CH476656; EDN05832.1; -; Genomic_DNA.
DR   RefSeq; XP_001542264.1; XM_001542214.1.
DR   AlphaFoldDB; A6QYH8; -.
DR   SMR; A6QYH8; -.
DR   STRING; 339724.A6QYH8; -.
DR   PRIDE; A6QYH8; -.
DR   EnsemblFungi; EDN05832; EDN05832; HCAG_02435.
DR   GeneID; 5449191; -.
DR   KEGG; aje:HCAG_02435; -.
DR   VEuPathDB; FungiDB:HCAG_02435; -.
DR   HOGENOM; CLU_015495_5_0_1; -.
DR   OMA; MGMRSNW; -.
DR   OrthoDB; 632707at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0031428; C:box C/D RNP complex; IEA:EnsemblFungi.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR   GO; GO:0017069; F:snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000494; P:box C/D RNA 3'-end processing; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:1902570; P:protein localization to nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0000452; P:snoRNA guided rRNA 2'-O-methylation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..635
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000350971"
FT   DOMAIN          284..414
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          445..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..483
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..499
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..552
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        590..635
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   635 AA;  69586 MW;  1283FAE6C8D87F1A CRC64;
     MTLFILAETS AGYALLKAKD KKLLKRHDIV AETQTAEGVS NLMKLKNFQK FDSAATALEE
     TASLVEGKVT PRLANLLESI KDEKKVSLAV ADPKLGNAIA KLPLAIQPIA DSTTTDLYRA
     IREHLPTLIP GLLPGDMSTM SLGLSHSLAR HKLKFSPDKI DTMIVQAIAL LDDLDKELNT
     YAMRVKEWYG WHFPELAKIL NDNIAYSKVV LKVGMRSNFG ETDLAEILPE EIEAVVKAAA
     DRSMGTEISN EDLDNIQALA EEVIGFSTYR QQLASYLAAR MTAIAPNLTA LVGELVGARL
     IAHAGSLVNL SKSPASTIQI LGAEKALFRA LKTKHDTPKY GLIYHASLIG QATGKNKGKM
     ARYLAAKAAI GLRVDALTDW PVDADGNEPT EEEKAALGMQ SRYYLEKKLA AMEGKPIKPR
     GVGIAPNGIP TAQPKKWEIN EARKYNPDAD GFAGDEDLAE SSPKKQKKEK KDKKKKLVEE
     IKESEDGSES EEESDEDVEM ADKSATNGSM ADANASSEER SDREEKSKKS KEKSLEKKSK
     KEDKKSKKQK SGSGPSVEEM AAKAGLSVSR YQRKLERGEI VFDSEGNPSY ISKKDLKKAK
     KEAKKAAKAA EKEAGKKRKR AEEDDEKKTK KKSKV