ID   NOP58_ASHGO             Reviewed;         513 AA.
AC   Q753I4;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Nucleolar protein 58;
GN   Name=NOP58; OrderedLocusNames=AFR328C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 508.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016819; AAS53699.2; -; Genomic_DNA.
DR   RefSeq; NP_985875.2; NM_211230.2.
DR   AlphaFoldDB; Q753I4; -.
DR   SMR; Q753I4; -.
DR   STRING; 33169.AAS53699; -.
DR   EnsemblFungi; AAS53699; AAS53699; AGOS_AFR328C.
DR   GeneID; 4622140; -.
DR   KEGG; ago:AGOS_AFR328C; -.
DR   eggNOG; KOG2572; Eukaryota.
DR   HOGENOM; CLU_015495_5_2_1; -.
DR   InParanoid; Q753I4; -.
DR   OMA; MGMRSNW; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0017069; F:snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000494; P:box C/D RNA 3'-end processing; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:1902570; P:protein localization to nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0000452; P:snoRNA guided rRNA 2'-O-methylation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..513
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000350972"
FT   DOMAIN          283..403
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          428..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..513
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  56702 MW;  340BE07C0BE1D5D8 CRC64;
     MAYVLTETAA GYALLKASDK KIYKSSSLVQ DLKSSENVLK QFKVAAFSKF ASAANALEEA
     NSVIEGKVSS QLEKLLAEAK SDKKSTLVVS ETKLANAINK LGLNFNVVCD AVTLDIYRAV
     KEYLPELLPG MTDGDLSKMS LGLAHSIGRH KLKFSADKVD VMIIQAIALL DDLDKELNTY
     AMRCKEWYGW HFPELAKIVT DSVAFARIIL TMGVRSNAAE TDMSEILPEE IEERVKSAAE
     VSMGTEITQV DLDNIKSLAE QIVEFAAYRE QLSNYLSSRM KAIAPNLTQL VGELVGARLI
     AHAGSLVSLA KAPASTIQIL GAEKALFRAL KTKHDTPKYG LLYHASLVGQ ATGKNKGKIA
     RVLAAKAAVS LRYDALAEDR DDSGDIGLEA RAKVESRLSQ LEGRDLRTTP KVSRDAKKIE
     ISEARAYNAD ADAATAPADS TPADSDDEEE EEKKVKKDKK DKKRKREEDA EEEDSKKSKK
     EKKEKKEKKE KKEKKEKKEK KEKKEKKEKK EKK