ID   NOP58_ASPCL             Reviewed;         592 AA.
AC   A1CL70;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Nucleolar protein 58;
GN   Name=nop58; ORFNames=ACLA_041100;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS027056; EAW09894.1; -; Genomic_DNA.
DR   RefSeq; XP_001271320.1; XM_001271319.1.
DR   AlphaFoldDB; A1CL70; -.
DR   SMR; A1CL70; -.
DR   STRING; 5057.CADACLAP00003768; -.
DR   EnsemblFungi; EAW09894; EAW09894; ACLA_041100.
DR   GeneID; 4702875; -.
DR   KEGG; act:ACLA_041100; -.
DR   VEuPathDB; FungiDB:ACLA_041100; -.
DR   eggNOG; KOG2572; Eukaryota.
DR   HOGENOM; CLU_015495_5_0_1; -.
DR   OMA; MGMRSNW; -.
DR   OrthoDB; 632707at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0031428; C:box C/D RNP complex; IEA:EnsemblFungi.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR   GO; GO:0017069; F:snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000494; P:box C/D RNA 3'-end processing; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:1902570; P:protein localization to nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0000452; P:snoRNA guided rRNA 2'-O-methylation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..592
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000350973"
FT   DOMAIN          285..410
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          443..592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..465
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..534
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..592
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   592 AA;  64689 MW;  756AF507AAC88A75 CRC64;
     MTLFILTETS AGYALLKAKD KKLLKRDDLA TEAATAEGVS NLVKLKSFQK FDSAAAALEE
     VASLVEGKVT PRLASLLDEI KDEKKVSLAV ADPKLGNAIG KLPGLDIQLI ADSTTADIYR
     AIREHLPTLI PGLLPQDMST MSLGLSHSLA RHKLKFSPDK IDTMIVQAIG LLDDLDKELN
     TYAMRVKEWY GWHFPELAKI LNDNIAYARL VLKMGMRSNW ETSDLAEILP EELEGPVKAA
     ADRSMGTEIS QDDLENIQAL AEQVVGFAEY RQQLAGYLTA RMNAIAPNLT ALVGDLVGAR
     LIAHAGSLTN LSKSPASTIQ ILGAEKALFR ALKTKHDTPK YGLIYHASLI GQATGKNKGK
     MARVLAAKAS LGIRVDALAD WEDDATEEDK AALGTEARYN LERKLAAMEG KPLKPRGVAI
     APNGASAQPK KFELNEARKY NADADALSSD EPKSKKDKKL IEEVSDEEMA DADSDEEPAA
     NGTKDDDSSD DSEEEKSKKH KSKKGKDAEL EKLAERAGLS LKRYKRKLER GEITFDADGN
     PTAVSKKDLK KAKKEAKKAS KGDEKKRKRS DDGEEVDNAE KKQKKKKKKG EE