NOP58_ASPNC
ID NOP58_ASPNC Reviewed; 580 AA.
AC A2QE38;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Nucleolar protein 58;
GN Name=nop58; ORFNames=An02g09260;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR EMBL; AM270022; CAK44334.1; -; Genomic_DNA.
DR RefSeq; XP_001400059.1; XM_001400022.2.
DR AlphaFoldDB; A2QE38; -.
DR SMR; A2QE38; -.
DR PaxDb; A2QE38; -.
DR PRIDE; A2QE38; -.
DR EnsemblFungi; CAK44334; CAK44334; An02g09260.
DR GeneID; 4979416; -.
DR KEGG; ang:ANI_1_1342024; -.
DR VEuPathDB; FungiDB:An02g09260; -.
DR HOGENOM; CLU_015495_5_0_1; -.
DR Proteomes; UP000006706; Chromosome 4R.
DR GO; GO:0031428; C:box C/D RNP complex; IEA:EnsemblFungi.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR GO; GO:0017069; F:snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0000494; P:box C/D RNA 3'-end processing; IEA:EnsemblFungi.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:1902570; P:protein localization to nucleolus; IEA:EnsemblFungi.
DR GO; GO:0000452; P:snoRNA guided rRNA 2'-O-methylation; IEA:EnsemblFungi.
DR Gene3D; 1.10.246.90; -; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR012974; NOP5_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; PTHR10894; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; SSF89124; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..580
FT /note="Nucleolar protein 58"
FT /id="PRO_0000350975"
FT DOMAIN 285..410
FT /note="Nop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT REGION 444..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..485
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 63339 MW; 2D23685459355BE4 CRC64;
MTLFILTETS AGYALLKAKD KKLLKRDDLA TEASTAEGVS NLLKLKSFQK FDSAATALEE
VASLVEGKVT PRLASLLDEV KDEKKVSLAV ADPKLGNAIG KLPGLSIELV ADSSTTDVFR
AIREHLPTLI PGLLPQDMST MSLGLSHSLA RHKLKFSPDK IDTMIVQAIG LLDDLDKELN
NYAMRVKEWY GWHFPELAKI LNDNIAYARL VLKMGMRTNW ESSDLAEILP EEIEGAVKAA
ADRSMGTEIS QEDLEHIQAL AEQVVGFAEY RQQLAGYLTA RMNAIAPNLT ALVGDLVGAR
LIAHAGSLTN LSKSPASTLQ ILGAEKALFR ALKTKHDTPK YGLIYHASLI GQATGKNKGK
MARVLAAKAS LGLRVDALAE WDDDATEEDK AALGTEARYN LERKLAAMEG KPLKPRGVAI
APNGAPQAQK FEINEARKYN ADADAVTGDE PASAKKSKSK KLVEEVQDEE MADAADSDEE
SDSSDEETDK KSKKSKDSEL EKLAEKAGLS LKRYKRKLER GEIQFDAEGN PSAVSKKDIK
KAKKEAKKSA KGEEKKRKRT DDGEVDNSEK KKKKKKKGEE
