ID   NOP58_ASPOR             Reviewed;         578 AA.
AC   Q2UC04;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Nucleolar protein 58;
GN   Name=nop58; ORFNames=AO090012000796;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; AP007161; BAE60911.1; -; Genomic_DNA.
DR   RefSeq; XP_001727750.1; XM_001727698.2.
DR   AlphaFoldDB; Q2UC04; -.
DR   SMR; Q2UC04; -.
DR   STRING; 510516.Q2UC04; -.
DR   PRIDE; Q2UC04; -.
DR   EnsemblFungi; BAE60911; BAE60911; AO090012000796.
DR   GeneID; 5988224; -.
DR   KEGG; aor:AO090012000796; -.
DR   VEuPathDB; FungiDB:AO090012000796; -.
DR   HOGENOM; CLU_015495_5_0_1; -.
DR   OMA; MGMRSNW; -.
DR   Proteomes; UP000006564; Chromosome 4.
DR   GO; GO:0031428; C:box C/D RNP complex; IEA:EnsemblFungi.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR   GO; GO:0017069; F:snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000494; P:box C/D RNA 3'-end processing; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:1902570; P:protein localization to nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0000452; P:snoRNA guided rRNA 2'-O-methylation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..578
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000350976"
FT   DOMAIN          285..410
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          443..578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..465
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..482
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..578
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   578 AA;  63392 MW;  4D11CE03B339DD5D CRC64;
     MTLFILTETS AGYALLKAKD KKLLKRDDLA TEAATAEGVS NLVKLKSFQK FDSAATALEE
     VASLVEGKVT PRLASLLDEV KDEKKVSLAV ADPKLGNAIG KLPGLDIQLI ADSTTTDIYR
     AIREHLPTLI PGLAPQDMST MSLGLSHSLA RHKLKFSPDK IDTMIVQAIG LLDDLDKELN
     NYAMRVKEWY GWHFPELAKI LNDNLAYAKL VLKMGMRTNW ESSDLAEILP EELEGSVKAA
     ADRSMGTEIS EEDLENIQAL AEQVVGFTEY RQQLAGYLTA RMNAIAPNLT ALVGELVGAR
     LIAHAGSLTN LSKSPASTLQ ILGAEKALFR ALKTKHDTPK YGLIYHASLI GQATGKNKGK
     MARVLAAKAS LGIRVDALAE WDEDATEEDK AALGIEARFN LERKLAGMEG KPLKPRGVTI
     APNGTPAQAK KFELNEARKY NADADAVDEP SSAKKQKKLV EEVQDTEMAD ADSDAEADSS
     DESEEESSKK KSKKSKDADL EKMAEKAGLS LKRYKRKLER GEIEFDAEGN PSSISKKDLK
     KAKKEAKKAD KGEEKKRKRS DDNEDNEKKQ KKKKKKDE