ID   NOP58_CANAL             Reviewed;         516 AA.
AC   Q59S06; A0A1D8PPD6; Q59RK5;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Nucleolar protein 58;
GN   Name=NOP58; OrderedLocusNames=CAALFM_C600370CA;
GN   ORFNames=CaO19.1199, CaO19.8790;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; CP017628; AOW29986.1; -; Genomic_DNA.
DR   RefSeq; XP_712316.1; XM_707223.1.
DR   AlphaFoldDB; Q59S06; -.
DR   SMR; Q59S06; -.
DR   BioGRID; 1229015; 3.
DR   STRING; 237561.Q59S06; -.
DR   PRIDE; Q59S06; -.
DR   GeneID; 3646084; -.
DR   KEGG; cal:CAALFM_C600370CA; -.
DR   CGD; CAL0000190357; NOP5.
DR   VEuPathDB; FungiDB:C6_00370C_A; -.
DR   HOGENOM; CLU_015495_5_2_1; -.
DR   InParanoid; Q59S06; -.
DR   OrthoDB; 632707at2759; -.
DR   PRO; PR:Q59S06; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IDA:CGD.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0017069; F:snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000494; P:box C/D RNA 3'-end processing; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR   GO; GO:1902570; P:protein localization to nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0000452; P:snoRNA guided rRNA 2'-O-methylation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..516
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000350979"
FT   DOMAIN          283..403
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          423..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..498
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..516
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   516 AA;  57115 MW;  74D9B04FC45E510B CRC64;
     MAYVLTETAA GYALLKAADK KIHKSSSLVE DLNTAEKVAE QFKIHRFEKF QSAANALEEA
     NAIIEGKVSE NLQKLLEDAK SDKKATLIVS EAKLGNAINK LGLNFQVVSD AASLDLQRAI
     KQFLPELLPG LDDSALKQMS LGLAHSMGRH KLKFSADKVD TMIIQAIALL DDLDKELNTY
     AMRCKEWYGW HFPELAKMIT DSAAYARIIL TMGVRSNASE TDLSEILPEE VEEQVKAAAE
     VSMGTEITED DLNNIKALAE QIVDFAAYRE QLSNYLSSRM KAIAPNLTAM VGELVGARLI
     AHAGSLTSLA KAPASTVQIL GAEKALFRAL KTKHDTPKYG IIYHASLVGQ ASGKNKGRIA
     RTLAAKAAVS LRYDCFDEER DESDDFGLEN RAKVEGRLSQ LEGRDMRTTS KVVREQPKVE
     ITEARAYNAD ADSTAAAAAA APTADSDDEE SETEEVEEKK SKKDKKKDKK EKKDKKKDKK
     RKRDDDKEDK ESSKKSKKDK KEKKEKKEKK AKKEKK