ID   NOP58_COCIM             Reviewed;         607 AA.
AC   Q1E1Q5; A0A0D6K9P2; J3KBU1;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Nucleolar protein 58;
GN   Name=NOP58; ORFNames=CIMG_03508;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; GG704916; EAS32484.1; -; Genomic_DNA.
DR   RefSeq; XP_001244067.1; XM_001244066.2.
DR   AlphaFoldDB; Q1E1Q5; -.
DR   SMR; Q1E1Q5; -.
DR   STRING; 246410.Q1E1Q5; -.
DR   PRIDE; Q1E1Q5; -.
DR   EnsemblFungi; EAS32484; EAS32484; CIMG_03508.
DR   GeneID; 4564539; -.
DR   KEGG; cim:CIMG_03508; -.
DR   VEuPathDB; FungiDB:CIMG_03508; -.
DR   InParanoid; Q1E1Q5; -.
DR   OMA; MGMRSNW; -.
DR   OrthoDB; 632707at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR   GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..607
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000350981"
FT   DOMAIN          285..415
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          419..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          446..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..482
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..500
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        501..598
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   607 AA;  66687 MW;  7CD62C9C863A7252 CRC64;
     MTLFILTETS AGYALLKAKD KKLLKRDDLE KETQTAEGVS NLLKLKNFQK FDSATTALEE
     VASLVEGKVT PRLASLLESI KDEKKVSLAV ADPKLGNAIG KLPGLSIQAI ADSTTADLYR
     AIRAHLPTLI PGLLPTDMST MALGLSHSLA RHKLKFSPDK IDTMIVQAIA LLDDLDKELN
     TYAMRVKEWY GWHFPEMAKI LNDNMAYAKV VLKMGMRSNS DSADLSEILP EEIEGAVKAA
     ANRSMGTDIS NEDLENIQCL AEQVVGFAEY RQQLASYLTA RMTAIAPNLT ALVGELVGAR
     LIAHAGSLVN LSKSPASTIQ ILGAEKALFR ALKTKHDTPK YGLIYHASLI GQATGKNKGK
     MARVLAAKAA IGLRVDALAE WEKDADGNEP TEEERAALGM ESRYYLEKKL AAMEGKPLKP
     RGVGIAPNGI PIEQPKKWDI KEARKHNPDA DGLTGDEPAA TENVSKKSKK DKKLVEEIKD
     EEMKDAPESE EEEEASEAEE SEEEKPKKSK KKESKTSKGK DSDEAKIEEL AEKAGLSVKR
     YLRKLERGEI NFDEDGNPTA ISKKELKKAK KEAKKAEKDA GKKRKRDEDE EPAESKSEKK
     KKKKSKA