ID   NOP58_CRYNB             Reviewed;         565 AA.
AC   P0CP27; Q55Q74; Q5KFZ2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Nucleolar protein 58;
GN   Name=NOP58; OrderedLocusNames=CNBF4620;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; AAEY01000033; EAL19927.1; -; Genomic_DNA.
DR   RefSeq; XP_774574.1; XM_769481.1.
DR   AlphaFoldDB; P0CP27; -.
DR   SMR; P0CP27; -.
DR   EnsemblFungi; EAL19927; EAL19927; CNBF4620.
DR   GeneID; 4937014; -.
DR   KEGG; cnb:CNBF4620; -.
DR   VEuPathDB; FungiDB:CNBF4620; -.
DR   HOGENOM; CLU_015495_5_2_1; -.
DR   Proteomes; UP000001435; Chromosome 6.
DR   GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR   GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..565
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000410170"
FT   DOMAIN          293..417
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          430..565
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..463
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..495
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        507..565
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   565 AA;  61979 MW;  41570781B93DEEF4 CRC64;
     MLVLTETSVG FVVFKLSSDA KIDNKDLWKE FETPEGANKA LKVQAIQRFT STASAVEDLT
     AVQDGRLTDS LSRFLLDTVG GADDGEKKKK KKKIEEMLVV SDPKLAGTIN KALSIPVLSD
     SSTQDLYRGI RQQLASLLGG VDQKDLNTMS LGLGHSLSRF KLKFSTDKVD TMVIQAIALL
     DDLDKEINIY AMRVKEWYGW HFPEMAKIIV DNIAFARVVK AMGFRTNAVT TDFSLLLPED
     LEATLKSAAE LSMGTEISDS DMTHIHSLCD QVISISEYRT QLSEYLRNRM QAIAPNLTAL
     VGELVGARLI SHAGSLMNLA KHPASTVQIL GAEKALFRAL KTKHDTPKYG LIYHASLIGQ
     APQKLKGKMA RMVATKAALS IRVDALSDAD SRSDVSAAEV GISNRVKLES RLRALEHQAG
     IQSVRKVVSA NGQQGRQQPR FEMSGVTGSY NAATDNVPLN GDLLPTQPAT EEVKEEKDEK
     KDKKKKRKSE VAEAGDVTMD GDADLSMVAG ETKEERRARK EAKKAAKAAK KAAEESGDGD
     KKSKKRRADE DEDSEKKKKK KKKDE