ID   NOP58_CRYNJ             Reviewed;         568 AA.
AC   P0CP26; Q55Q74; Q5KFZ2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Nucleolar protein 58;
GN   Name=NOP58; OrderedLocusNames=CNF00090;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; AE017346; AAW43972.1; -; Genomic_DNA.
DR   RefSeq; XP_571279.1; XM_571279.1.
DR   AlphaFoldDB; P0CP26; -.
DR   SMR; P0CP26; -.
DR   STRING; 5207.AAW43972; -.
DR   PaxDb; P0CP26; -.
DR   EnsemblFungi; AAW43972; AAW43972; CNF00090.
DR   GeneID; 3258236; -.
DR   KEGG; cne:CNF00090; -.
DR   VEuPathDB; FungiDB:CNF00090; -.
DR   eggNOG; KOG2572; Eukaryota.
DR   HOGENOM; CLU_015495_5_2_1; -.
DR   InParanoid; P0CP26; -.
DR   OMA; MGMRSNW; -.
DR   OrthoDB; 632707at2759; -.
DR   Proteomes; UP000002149; Chromosome 6.
DR   GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..568
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000350982"
FT   DOMAIN          293..417
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          430..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..463
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..498
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..568
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   568 AA;  62350 MW;  46BE211C3D741470 CRC64;
     MLVLTETSVG FVVFKLSSDA KIDNKDLWKE FETPEGANKA LKVQAIQRFT STASAVEDLT
     AVQDGRLTDS LSRFLLDTVG GADDGEKKKK KKKIEEMLVV SDPKLAGTIN KALSIPVLSD
     SSTQDLYRGI RQQLASLLGG VDQKDLNTMS LGLGHSLSRF KLKFSTDKVD TMVIQAIALL
     DDLDKEINIY AMRVKEWYGW HFPEMAKIIV DNIAFARVVK AMGFRTNAVT TDFSLLLPED
     LEATLKSAAE LSMGTEISDS DMTHIHSLCD QVISISEYRT QLSEYLRNRM QAIAPNLTAL
     VGELVGARLI SHAGSLMNLA KHPASTVQIL GAEKALFRAL KTKHDTPKYG LIYHASLIGQ
     APQKLKGKMA RMVATKAALS IRVDALSDAD SRSDVSAAEV GISNRVKLES RLRALEHQAG
     IQSVRKVVSA NGQQGRQQPR FEMSGVTGSY NAATDNVPLN GDLLPTQPAT EEVKEEKDEK
     KDKKDKKKKR KSEVAEAGDV TMDGDADLSM VAGETKEERR ARKEAKKAAK AAKKAAEESG
     DGDKKSKKRR ADEDEDSEKK KKKKKKDE