ID   NOP58_DICDI             Reviewed;         638 AA.
AC   Q55FI4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Nucleolar protein 58;
DE   AltName: Full=Nucleolar protein 5;
GN   Name=nop58; Synonyms=nol5, nop5; ORFNames=DDB_G0268098;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for 60S ribosomal subunit biogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73502.1; -; Genomic_DNA.
DR   RefSeq; XP_647549.1; XM_642457.1.
DR   AlphaFoldDB; Q55FI4; -.
DR   SMR; Q55FI4; -.
DR   STRING; 44689.DDB0305289; -.
DR   PaxDb; Q55FI4; -.
DR   PRIDE; Q55FI4; -.
DR   EnsemblProtists; EAL73502; EAL73502; DDB_G0268098.
DR   GeneID; 8616357; -.
DR   KEGG; ddi:DDB_G0268098; -.
DR   dictyBase; DDB_G0268098; nop58.
DR   eggNOG; KOG2572; Eukaryota.
DR   HOGENOM; CLU_015495_5_2_1; -.
DR   InParanoid; Q55FI4; -.
DR   OMA; TATQELM; -.
DR   PhylomeDB; Q55FI4; -.
DR   Reactome; R-DDI-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q55FI4; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..638
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000331207"
FT   DOMAIN          284..402
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          416..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..440
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..462
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..638
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  72336 MW;  ADF925E316A2718C CRC64;
     MLVLFETSAG FALFKVLDEG KMKSKPVDIN NFFETPEKAS SFVSLKKFYK FDGTLDALEA
     QTAIAECKVP ESLSNFLKKN VVSEKLNEQL IVSDSKFGNA IKDALNIKVL CDDTTQELIR
     GIRLQLKSLV NANEQDLNAM SIGLSHSYSR YKLKFSPDKV DTMIVQAISL LDDLTTEINI
     YAMRAREWYG WHFPELGKLI TNHTQYANAI KAMGNRKSAV DTDFTDILPE EVAEEVKEAA
     QISMGTEISP EDLDHIFALC DQFLSIQAYH TELTEYLKSR MEAIAPNLTI LVGEIVGARL
     ICRAGSLMNL AKYPASTIQI LGAEKALFRA LKTKHNTPKY GLIYNAKIVG EASLKNKGKM
     SRVLAAKAAL SARFDALCEV SDTSYGIAYK GAVDRRAAAI EGREVRKSLN AVKPEKSGNV
     AKYDHTKSAT TNTTRDVATK SSKESSIKQE KQDVKMEEAS SSDSDSSSDS DSSEEEKSKK
     SKKSKKEETP VAKEEKKEKK SKKEETPVAK EEKKEKEEKK EKKDKKEKKE EKEDKKEEKK
     EKKDKKEKTE ETPVAKEEKK EKKEKKEEKE EKKDKKEKKE KKEEKEEKKE KKEKKSSSKE
     DKKEKEEKKE KKSSSKEDKK RKDRDEEPEE KKSKKSKK