NOP58_NEUCR
ID NOP58_NEUCR Reviewed; 597 AA.
AC Q8X066;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Nucleolar protein 58;
GN Name=nop-58; ORFNames=B19C19.070, NCU03396;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR EMBL; AL669992; CAD21145.1; -; Genomic_DNA.
DR EMBL; CM002237; EAA27607.1; -; Genomic_DNA.
DR RefSeq; XP_956843.1; XM_951750.3.
DR AlphaFoldDB; Q8X066; -.
DR SMR; Q8X066; -.
DR STRING; 5141.EFNCRP00000002638; -.
DR PRIDE; Q8X066; -.
DR EnsemblFungi; EAA27607; EAA27607; NCU03396.
DR GeneID; 3872990; -.
DR KEGG; ncr:NCU03396; -.
DR VEuPathDB; FungiDB:NCU03396; -.
DR HOGENOM; CLU_015495_5_0_1; -.
DR InParanoid; Q8X066; -.
DR OMA; MGMRSNW; -.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0017069; F:snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0000494; P:box C/D RNA 3'-end processing; IEA:EnsemblFungi.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:1902570; P:protein localization to nucleolus; IEA:EnsemblFungi.
DR GO; GO:0000452; P:snoRNA guided rRNA 2'-O-methylation; IEA:EnsemblFungi.
DR Gene3D; 1.10.246.90; -; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR012974; NOP5_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; PTHR10894; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; SSF89124; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..597
FT /note="Nucleolar protein 58"
FT /id="PRO_0000350988"
FT DOMAIN 285..410
FT /note="Nop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT REGION 452..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..551
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 66082 MW; EFBC068FB4D4439A CRC64;
MPLFILTETS AGYGLFKAAD KKLLSSDNLA ERLNSVEKIT KEIKYKEFAK FESAATALEE
IAGVVEGKVT PKLNSLLAEI GNEKKVTLAV AESKLGAAIN KIPNLDIQPI ADSTTTDLFR
AIRQYLPELI PGMLPENFKE MSLGLSHSLS RHKLKFSPEK VDVMIVHAVS LLDELDKELN
TYAMRVKEWY GWHFPELAKI LPDNLSYARI IVTMGMRSNA TTADLSEILP HEIEAAVKAA
ADISMGTEVS EEDLQNIKYL AERVIDYSVY RKQLSDYLEN RMRAIAPNMT ELVGALVGAR
LIAHAGSVMN LAKNPGSTIQ ILGAEKALFR ALKTKHATPK YGLIYHASLV GQASGANKGK
MARQLASKVA LGVRTDALAE FPEDADDETR ASLGIRSRAK LENNLRQLEG KPIASKGVSV
GPNGIPVASA PKWDIKEARK YNIDADGLAA DAEAPKKPLI QEVEMQDAPA DEDEEMKDVS
KKSKKDKKEK KEKKDKKAKK ELDDEDFERL AKAAGMSVDK FKRRFERGQI SIKEDGTLEI
LSKKDFKGKD AEAEEEAEEE EKPAKKSKSS KRKAEAEEEE TTKEEKPKKK KKKSSKE
