ID   NOP58_PICGU             Reviewed;         504 AA.
AC   A5DHW0;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Nucleolar protein 58;
GN   Name=NOP58; ORFNames=PGUG_02861;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; CH408157; EDK38763.2; -; Genomic_DNA.
DR   RefSeq; XP_001485132.1; XM_001485082.1.
DR   AlphaFoldDB; A5DHW0; -.
DR   SMR; A5DHW0; -.
DR   STRING; 4929.XP_001485132.1; -.
DR   EnsemblFungi; EDK38763; EDK38763; PGUG_02861.
DR   GeneID; 5127371; -.
DR   KEGG; pgu:PGUG_02861; -.
DR   VEuPathDB; FungiDB:PGUG_02861; -.
DR   eggNOG; KOG2572; Eukaryota.
DR   HOGENOM; CLU_015495_5_2_1; -.
DR   InParanoid; A5DHW0; -.
DR   OMA; MGMRSNW; -.
DR   OrthoDB; 632707at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR   GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..504
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000350989"
FT   DOMAIN          283..403
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          405..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          446..504
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        405..421
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..492
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   504 AA;  56173 MW;  7FADA3FF3E4DF448 CRC64;
     MAYVLTETAA GYALLKAADK KIYKSTTLLE DLDTAEKVAE QFKVHRFEKF SSAAGALEEA
     NAVIEGRVSE TLKKFLSEVK QDKKATLVVS ETKLGNAINK LGLNFSVVSD AASLDLHRSI
     REFLPELLPG LDDNALKQMS LGLAHSIGRH KLKFSADKVD TMIVQAIALL DDLDKELNTY
     AMRCKEWYGW HFPELAKMIT DSVAYARIIL TMGIRSNASE TDLSEILPEE MEEKVKTAAE
     VSMGTEITPI DLENIKALAE QIVDFAAYRE QLSNYLSARM KAIAPNLTAL VGELIGARLI
     AHAGSLTSLS KAPASTIQIL GAEKALFRAL KTKHDTPKYG LLYHASLVGQ ATGKNKGKIA
     RVLAAKAAVA LRYDSLSEER DDSGDFGFSV RAKVESRLSA LEGRDMRTTS KVVREQQKIE
     IKEAPQYNAD ADAGGDSDDE EEEEEPEKKE KKEKKDKKEK KEKKEKKEKK EKKDKKRKRD
     EDDEDDKKKS KKDKKSKKEK KEKK