ID   NOP58_YEAS7             Reviewed;         511 AA.
AC   A6ZPE5;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Nucleolar protein 58;
DE   AltName: Full=Nucleolar protein 5;
GN   Name=NOP58; Synonyms=NOP5; ORFNames=SCY_5360;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Required for pre-18S rRNA processing. May bind microtubules
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SIK1/NOP56 and NOP1. Interacts with the
CC       trimethylguanosine synthase TGS1. Component of the ribosomal small
CC       subunit (SSU) processome composed of at least 40 protein subunits and
CC       snoRNA U3 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
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DR   EMBL; AAFW02000032; EDN63635.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZPE5; -.
DR   SMR; A6ZPE5; -.
DR   IntAct; A6ZPE5; 3.
DR   MINT; A6ZPE5; -.
DR   PRIDE; A6ZPE5; -.
DR   EnsemblFungi; EDN63635; EDN63635; SCY_5360.
DR   HOGENOM; CLU_015495_5_2_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR   GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.246.90; -; 1.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR012974; NOP5_N.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; PTHR10894; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF08156; NOP5NT; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; SSF89124; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Isopeptide bond; Nucleus; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Ubl conjugation.
FT   CHAIN           1..511
FT                   /note="Nucleolar protein 58"
FT                   /id="PRO_0000350996"
FT   DOMAIN          283..403
FT                   /note="Nop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT   REGION          423..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          435..511
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        448..495
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..511
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        281
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250|UniProtKB:Q12499"
SQ   SEQUENCE   511 AA;  56956 MW;  C075BD498880CBA7 CRC64;
     MAYVLTETSA GYALLKASDK KIYKSSSLIQ DLDSSDKVLK EFKIAAFSKF NSAANALEEA
     NSIIEGKVSS QLEKLLEEIK KDKKSTLIVS ETKLANAINK LGLNFNVVSD AVTLDIYRAI
     KEYLPELLPG MSDNDLSKMS LGLAHSIGRH KLKFSADKVD VMIIQAIALL DDLDKELNTY
     AMRCKEWYGW HFPELAKIVT DSVAYARIIL TMGIRSKASE TDLSEILPEE IEERVKTAAE
     VSMGTEITQT DLDNINALAE QIVEFAAYRE QLSNYLSARM KAIAPNLTQL VGELVGARLI
     AHSGSLISLA KSPASTIQIL GAEKALFRAL KTKHDTPKYG LLYHASLVGQ ATGKNKGKIA
     RVLAAKAAVS LRYDALAEDR DDSGDIGLES RAKVENRLSQ LEGRDLRTTP KVVREAKKVE
     MTEARAYNAD ADTAKAASDS ESDSDDEEEE KKEKKEKKEK KRKRDDDEDS KDSKKAKKEK
     KDKKEKKEKK EKKEKKEKKE KKSKKEKKEK K