NOP5A_ARATH
ID NOP5A_ARATH Reviewed; 533 AA.
AC O04658; Q8H0T7; Q9FPT6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Probable nucleolar protein 5-1;
DE AltName: Full=MAR-binding NOP56/58 homolog 1;
DE AltName: Full=NOP58-like protein F108;
DE AltName: Full=Nucleolar protein 58-1;
GN Name=NOP5-1; Synonyms=NOP58-1; OrderedLocusNames=At5g27120;
GN ORFNames=T21B4_30, TM021B04.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Phelan T.J., Spiker S.L.;
RT "Arabidopsis MAR binding NOP56/58 homologs.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=cv. Landsberg erecta;
RX PubMed=17272265; DOI=10.1074/mcp.m600408-mcp200;
RA Maor R., Jones A., Nuehse T.S., Studholme D.J., Peck S.C., Shirasu K.;
RT "Multidimensional protein identification technology (MudPIT) analysis of
RT ubiquitinated proteins in plants.";
RL Mol. Cell. Proteomics 6:601-610(2007).
CC -!- FUNCTION: Required for 60S ribosomal subunit biogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB61073.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF302490; AAG40836.1; -; mRNA.
DR EMBL; AF007271; AAB61073.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED93652.1; -; Genomic_DNA.
DR EMBL; AY074281; AAL66978.1; -; mRNA.
DR EMBL; AY096684; AAM20318.1; -; mRNA.
DR EMBL; BT002060; AAN72071.1; -; mRNA.
DR PIR; T01807; T01807.
DR RefSeq; NP_198064.1; NM_122594.3.
DR AlphaFoldDB; O04658; -.
DR SMR; O04658; -.
DR BioGRID; 18044; 41.
DR IntAct; O04658; 3.
DR STRING; 3702.AT5G27120.1; -.
DR iPTMnet; O04658; -.
DR PaxDb; O04658; -.
DR PRIDE; O04658; -.
DR ProteomicsDB; 250539; -.
DR EnsemblPlants; AT5G27120.1; AT5G27120.1; AT5G27120.
DR GeneID; 832770; -.
DR Gramene; AT5G27120.1; AT5G27120.1; AT5G27120.
DR KEGG; ath:AT5G27120; -.
DR Araport; AT5G27120; -.
DR TAIR; locus:2181211; AT5G27120.
DR eggNOG; KOG2572; Eukaryota.
DR HOGENOM; CLU_015495_5_2_1; -.
DR InParanoid; O04658; -.
DR OMA; KHQTEDV; -.
DR OrthoDB; 632707at2759; -.
DR PhylomeDB; O04658; -.
DR PRO; PR:O04658; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; O04658; baseline and differential.
DR Genevisible; O04658; AT.
DR GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.246.90; -; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR012974; NOP5_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; PTHR10894; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; SSF89124; 1.
DR PROSITE; PS51358; NOP; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..533
FT /note="Probable nucleolar protein 5-1"
FT /id="PRO_0000219031"
FT DOMAIN 280..398
FT /note="Nop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00690"
FT REGION 402..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..426
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 58755 MW; CD8C0EE4895D8A13 CRC64;
MLILFETPGG FAIFKVLNEG KLSNVEDLGN EFSTAKLARK MVKLVAFDKF DNTAEALEAV
AKLLEGTPSK GLRKFLKANC VGETLAVADS KLGNIIKEKL KIVCVHNNAV MELLRGIRSQ
LTELISGLGD QDLGPMSLGL SHSLARYKLK FSSDKVDTMI IQAIGLLDDL DKELNTYAMR
VREWFGWHFP ELAKIVQDNI LYAKAVKLMG NRINAAKLDF SEILADEIEA ELKEAAVISM
GTEVSDLDLL HIRELCDQVL SLAEYRAQLY DYLKSRMNTI APNLTALVGE LVGARLISHG
GSLLNLAKQP GSTVQILGAE KALFRALKTK HATPKYGLIF HASVVGQAAP KNKGKISRSL
AAKSVLAIRC DALGDSQDNT MGVENRLKLE ARLRTLEGKD LGRLSGSAKG KPKIEVYDKD
KKKGSGGLIT PAKTYNTAAD SLLQTPTVDS ENGVKEKKDK KKKKKADDEE EAKTEEPSKK
KSNKKKTEAE PETAEEPAKK EKKKKRKHEE EETEMPAKKK EKSEKKKKKK TEV
