NOP9_ASHGO
ID NOP9_ASHGO Reviewed; 678 AA.
AC Q75C70;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Nucleolar protein 9;
DE AltName: Full=Pumilio domain-containing protein NOP9;
GN Name=NOP9; OrderedLocusNames=ACR046W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC processing. Involved in production of 18S rRNA and assembly of small
CC ribosomal subunit (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP9 family. {ECO:0000305}.
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DR EMBL; AE016816; AAS51273.2; -; Genomic_DNA.
DR RefSeq; NP_983449.2; NM_208802.2.
DR AlphaFoldDB; Q75C70; -.
DR SMR; Q75C70; -.
DR STRING; 33169.AAS51273; -.
DR EnsemblFungi; AAS51273; AAS51273; AGOS_ACR046W.
DR GeneID; 4619574; -.
DR KEGG; ago:AGOS_ACR046W; -.
DR eggNOG; KOG2188; Eukaryota.
DR HOGENOM; CLU_008720_1_1_1; -.
DR InParanoid; Q75C70; -.
DR OMA; TPNGSHI; -.
DR Proteomes; UP000000591; Chromosome III.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000056; P:ribosomal small subunit export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040000; NOP9.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13102; PTHR13102; 1.
DR SMART; SM00025; Pumilio; 8.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..678
FT /note="Nucleolar protein 9"
FT /id="PRO_0000407795"
FT REPEAT 91..126
FT /note="Pumilio 1"
FT REPEAT 127..162
FT /note="Pumilio 2"
FT REPEAT 189..224
FT /note="Pumilio 3"
FT REPEAT 288..326
FT /note="Pumilio 4"
FT REPEAT 338..373
FT /note="Pumilio 5"
FT REPEAT 375..411
FT /note="Pumilio 6"
FT REPEAT 515..552
FT /note="Pumilio 7"
FT REPEAT 553..591
FT /note="Pumilio 8"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 678 AA; 78248 MW; 806BB82538A6C4F6 CRC64;
MAKQRGRKLL QKQNKDDFKH SLDQERHEEE VIQVPVDKAP APISADGPNT FFGTLDTQEL
EYFKRAESTM AVDTFESADE KYQFINSVIE ESKGKELKLA TSQICSKLME RIILAADDQQ
LKAIFQGING FFVNLSYNKY ASHVVETLLV RSAALIEKEL LTPVFEAELD GDEQVYASME
NMFLFMLNEL KPHMKMMINH QYASHVFRLL ILVLSAKKLP KSTQSNSALR SKKSKIARKM
VDLKDNADFD RTYRTPDSFK LELKGILVML YKQFTNGIEP GTKHSEVNIA CVTKFREYCV
DKVASPVIQL IIQVEGIFDR DRSFWNLVFS NTEQNDPKEE SFMEYLLSDS VGSHFLQAVI
GFARTKQVER LYKLYMQDRI VKLAKRDTTG AFVIMSLLQN LGSKEVKSIL DDLVPELSIL
LNSNLDFGSE IIEASIRQGD YKKTEIVEQL GKKYYPADSE SKNILESCLQ LASSTLGNTK
DDWPTADERR RALFLEKLIN FDDYFLEIAV ESLLNLPEER IMQMCYHGVF SHVVEHVLQA
KRVETVKRKL LLNILYKDAV NLACNAYGSH IMDKLWEFTA KLTLYKERIA NLLLEEADKV
KNSIYGRQVW KNWHLELYVR KRFDWRKKVK EQELEVFPDS KPLQPKQKES IPAKRSAPSN
NQRPGSLNKK RNAEKHHT